多针孔心脏SPECT成像系统设计与性能评估

System Design and Performance Evaluation for Cardiac SPECT Imaging with Multi-pinhole Collimator

单光子发射计算机断层成像技术(SPECT)是放射性核素心脏显像重要的成像手段之一。受传统SPECT的平行孔准直器的灵敏度和空间分辨率的影响,SPECT心脏成像的图像质量不佳。本文在临床SPECT系统的双探头基础上,通过设计高灵敏度、高空间分辨率的多针孔准直器,取代传统的平行孔准直器,实现高性能的心脏成像。通过解析计算对系统性能进行了评估,结果表明:中心灵敏度为0.038%,空间分辨率为1 cm,优于传统的平行孔SPECT。基于数值模拟的心肌成像实验,获得了高质量的心肌重建图像,证明了基于多针孔准直器心脏SPECT成像的设计可行性。

SPECT is one of the powerful tools for radionuclide cardiac imaging.However,the image quality of cardiac SPECT imaging usually is degraded by the poor sensitivity and spatial resolution of conventional SPECT parallel-hole collimator.Based on the two detectors from a clinical SPECT scanner,multi-pinhole collimator was designed,which was used to replace the conventional parallel-hole collimator,for the cardiac imaging with high performance.The system performance was evaluated with analytical calculation.The results show that the central sensitivity is 0.038%,the spatial resolution is 1 cm,and it is better than that of the conventional SPECT.The projection with myocardial phantom was simulated.The reconstruction image with high quality was obtained by using iterative reconstruction algorithm.All the results demonstrate the feasibility of our proposed design of the cardiac SPECT with multi-pinhole collimator.