摘要
随着近十年全基因组测序等分子生物学技术飞速发展,非编码RNA得到深度挖掘,环状RNA(circRNA)也逐渐成为近年的研究热门。circRNA在多种疾病的发生发展过程中发挥重要作用,在眼科学疾病中也已展开相关研究。本文将重点对环状RNA的机制以及在各种眼科疾病中的基础研究和临床发现进行综述,并就circRNA在眼科疾病中的潜在临床意义作简要探讨。
With the rapid development of molecular biology technologies such as whole-genome testing in the past decade,non-coding RNA has been deeply explored.Circular RNA(circRNA)gradually becomes a hot topic in recent years,which plays an important role in the occurrence and development of a variety of diseases,and relevant studies have been carried out in ophthalmological diseases.This article will review the mechanism,basic research,and clinical findings of circRNA in various ophthalmic diseases,and briefly discuss the potential clinical significance of circRNA in ophthalmic diseases.
作者
束炼
陈晓晓
孙兴怀
Lian Shu;Xiao-Xiao Chen;Xing-Huai Sun(Department of Ophthalmology&Visual Science,Shanghai Medical College,Fudan University,Shanghai 200031,China;Department of Ophthalmology,Eye&ENT Hospital of Fudan University,Shanghai 200031,China;State Key Laboratory of Medical Neurobiology,Fudan University,Key Laboratory of Myopia,Chinese Academy of Medical Sciences,Shanghai Key Laboratory of Visual Impairment and Restoration,Shanghai 200031,China)
出处
《国际眼科杂志》
CAS
北大核心
2021年第8期1378-1382,共5页
International Eye Science
基金
国家自然科学基金重点项目(No.81430007)。
