血液透析与腹膜透析治疗终末期糖尿病肾病的临床疗效比较

Comparison of Clinical Efficacy Between Hemodialysis and Peritoneal Dialysis in the Treatment of End-stage Diabetic Nephropathy

目的探讨血液透析与腹膜透析用于治疗终末期糖尿病肾病的临床价值。方法随机将医院2018年3月—2019年3月收治的86例终末期糖尿病肾病患者分为两组,每组43例。观察组给予腹膜透析方案,对照组给予常规血液透析方案。比较两组总有效率、生化指标以及并发症情况等。结果(1)观察组总有效率(95.35%,41/43)明显高于对照组(79.07%,34/43),差异有统计学意义(P<0.05);(2)观察组肌酐、血浆总蛋白、尿素氮以及24 h蛋白尿水平分别为(336.91±18.74)μmol/L、(61.16±3.62)g/L、(18.64±1.59)mmol/L、(365.12±5.45)mg;对照组分别为(460.19±14.81)μmol/L、(50.85±4.09)g/L、(23.68±1.73)mmol/L、(480.49±8.74)mg;两组比较差异有统计学意义(P<0.05);(3)观察组不良反应发生率(2.33%,1/43)明显低于对照组(20.93%,9/43),差异有统计学意义(P<0.05)。结论腹膜透析治疗终末期糖尿病肾病效果显著。

Objective To explore the clinical value of hemodialysis and peritoneal dialysis in the treatment of end-stage diabetic nephropathy.Methods The 86 patients with end-stage diabetic nephropathy who were treated in our hospital from March 2018 to March 2019 were randomly divided into two groups,with 43 cases in each group.The observation group was given a peritoneal dialysis program,and the control group was given a conventional hemodialysis program.The total effective rate,biochemical indicators and complications of the two groups were compared.Results(1)The total effective rate of the observation group(95.35%,41/43)was significantly higher than that of the control group(79.07%,34/43),the difference was statistically significant(P<0.05).(2)The observation group’s creatinine,plasma total protein,the level of urea nitrogen and 24-hour proteinuria were(336.91±18.74)μmol/L,(61.16±3.62)g/L,(18.64±1.59),(365.12±5.45)mg,respectively;the control group was(460.19±14.81)μmol/L,(50.85±4.09)g/L,(23.68±1.73)mmol/L,(480.49±8.74)mg;with significant differences between the two groups(P<0.05).(3)The incidence of adverse reactions in the observation group(2.33%,1/43)was significantly lower than the control group(20.93%,9/43),and the difference was significant(P<0.05).Conclusion Peritoneal dialysis is effective in the treatment of end-stage diabetic nephropathy.