丁苯酞联合脑循环治疗仪对脑梗死患者的疗效

Curative Effect of Butylphthalide Combined With Cerebral Circulation Therapeutic Instrument in Patients With Cerebral Infarction

目的探究急性脑梗死患者施行丁苯肽联合脑循环治疗仪的临床疗效,并对神经功能和脑循环状态的影响。方法回顾2018年5月—2020年5月收治急性脑梗死共86例患者资料,结合疗法差异分成联合组45例和参照组41例。参照组施行急性脑梗死常规治疗。联合组在施行脑循环治疗仪基础上给予丁苯肽氯化钠注射液,对比两组于神经缺损得分(national institute of health stroke scale,NIHSS)、血基质金属蛋白酶2(matrix metalloproteinase-2,MMP-2)含量上的差异性,并利用多普勒超声评估治疗前后颈内动脉平均血流速度、脑血管阻力变化。结果联合组NIHSS量表评分及MMP-2表达水平明显低于参照组,比较差异有统计学意义(P<0.05);联合组治疗后颈内动脉平均血流速度比参照组有一定程度上升,脑血管阻力比参照组有一定降低(P<0.05)。结论脑循环治疗仪联合丁苯肽氯化钠注射液治疗在急性脑梗死治疗方面有显著疗效,改善患者神经功能缺损和改善脑循环状态。

Objective To study the impact of butylphthalide and cerebral circulation therapy apparatus on neurological function and cerebral circulation states of acute cerebral infraction patients.Methods Clinical data about 86 acute cerebral infraction patients from May 2018 to May 2020 was acquired.According to different therapies,patients were assigned to combined group(45 cases)and reference group(41 cases).Reference group was used the routine acute cerebral infraction treatment;the combined group was used the cerebral circulation therapy apparatus and butylphthalide sodium chloride injection.National institute of health stroke scale(NIHSS)scores and matrix metalloproteinase-2(MMP-2)contents were compared;mean flow velocity of internal carotid artery and cerebral vascular resistance were appraised by color Doppler ultrasound.Results NIHSS scores and MMP-2 expressions in combined group were lower than reference group,with statistically significant difference(P<0.05);compared with reference group,the mean flow velocity of internal carotid artery in combined group was increased while cerebral vascular resistance was declined at a certain extent(P<0.05).Conclusion Cerebral circulation therapy apparatus combined with butylphthalide and sodium chloride injection has obvious effects in acute cerebral infraction patients,which can improve the neurologic impairment and cerebral circulation states.