摘要
目的评价右美托咪啶(dexmedetomidine,DEX)对唤醒麻醉下脑功能区手术唤醒质量和术后痛觉过敏的影响。方法择期拟行脑功能区肿瘤切除术病人45例,随机分为3组:丙泊酚复合瑞芬太尼组(R组)、DEX复合丙泊酚与瑞芬太尼组(D组)、生理盐水复合丙泊酚与瑞芬太尼对照组(C组)。记录术前、术后24、48、72 h的机械痛阈值以及术后72 h内的不良反应,并进行统计学分析。结果D组在术后各时间点痛阈值均明显高于R组及C组(P<0.05);而R组与C组在术后各时间点痛阈值差异无统计学意义(P>0.05)。3组间疼痛视觉模拟评分(visual analogue scale,VAS)及头晕头痛发生率差异均无统计学意义(P>0.05)。结论DEX用于唤醒麻醉下脑功能区手术不影响唤醒质量,且可抑制病人术后机械痛阈值降低,预防发生痛觉过敏。
Objective To observe the effects of dexmedetomidine(Dex)on quality of wake-up and postoperative hyperalgesia in eloquent brain area surgery underawake anesthesia.Methods Resection of eloquent brain area tumors were performed in 45 patients,who were randomly divided into three groups:propofol combined with remifentanil group(group R),Dex combined with propofol and remifentanil group(group D)and normal saline combined with propofol and remifentanil group(group C).Mechanical pain thresholds before the operation,and 24,48 and 72 h after the operation,and adverse reactions within 72 h after the operation were recorded and analyzed statistically.Results Mechanical pain thresholds in group D were obviously higher than those in group R and group C in every time point after the operation(P<0.05),while there was no significant difference in mechanical pain thresholds at every time point after the operation between group R and group C(P>0.05).Moreover,no significant difference was found in visual analogue scale(VAS)scores and the incidence rate of adverse reactions between the three groups(P>0.05).Conclusion Dex can increase postoperative mechanical pain threshold and prevent postoperative hyperalgesia without affecting the quality of wake-up in eloquent brain area surgery under awake anesthesia.
作者
吴昊澎
孙梅
饶云
杨秀环
何洹
彭捷
陆建华
Wu Haopeng;Sun Mei;Rao Yun;Yang Xiuhuan;He Huan;Peng Jie;Lu Jianhua(Department of Anesthesiology,General Hospital of Southern Theatre Command,Guangzhou,Guangdong 510010,China)
出处
《中国微侵袭神经外科杂志》
CAS
2021年第5期193-196,共4页
Chinese Journal of Minimally Invasive Neurosurgery
基金
国家自然科学基金面上项目/常规面上项目(编号:81371233)
广州市科技计划项目(编号:201804010060)。
关键词
右美托咪啶
痛觉过敏
唤醒麻醉
手术
脑功能区
脑肿瘤
dexmedetomidine
hyperalgesia
awake anesthesia
surgery,eloquent brain area
brain neoplasms