不同手术方式对颞叶低级别胶质瘤相关癫痫的研究

Clinical study of different surgical methods for epilepsy associated with low-grade temporal glioma

目的探讨颞叶低级别胶质瘤相关癫痫不同手术方式的临床疗效。方法回顾性分析89例颞叶低级别胶质瘤所致癫痫病例资料,根据手术方式分为标准前颞叶联合海马、杏仁核切除组(扩大组,n=47)和标准前颞叶切除组(标准组,n=42)。比较两组术后并发症、术后12个月Engel分级及ADL评分差异。结果两组间术后并发症差异,无统计学意义(P>0.05)。术后Engel分级与ADL评分,扩大组比标准组更佳(均P<0.05)。结论与单纯标准前颞叶切除比较,颞叶低级别胶质瘤相关癫痫采用标准前颞叶联合海马、杏仁核切除,能更有效控制癫痫,不会增加并发症,生活质量更高。

Objective To investigate the clinical effects of different surgical methods for low-grade glioma-related epilepsy in the temporal lobe.Methods The clinical data of 89 patients with epilepsy caused by low-grade temporal glioma were analyzed retrospectively.According to the surgical method,they were divided into standard anterior temporal lobe combined with hippocampus and amygdala resection group(enlarged group,n=47),and standard anterior temporal lobe resection group(standard group,n=42).The differences in postoperative complications,Engel grade and ADL score at 12 months after operation were compared between the two groups.Results There was no statistically significant difference in postoperative complications between the two groups(P>0.05).After operation,the Engel classification and ADL score were better in the enlarged group than the standard group(both P<0.05).Conclusions Compared with standard anterior temporal lobe resection,standard anterior temporal lobe combined with hippocampus and amygdala resection for epilepsy associated with low-grade temporal lobe can control epilepsy more effectively without increasing complications and have a higher quality of life.