绝经后骨质疏松症患者血清白细胞介素31水平与骨密度相关性

Correlation between Serum Interleukin-31 and Bone Mineral Density in Postmenopausal Osteoporosis Patients

目的观察绝经后骨质疏松症(OP)患者血清白细胞介素31(IL-31)水平与骨密度相关性分析。方法将我院(2018年1月至2019年12月)收治绝经后OP患者总计60例为研究组,并根据患者的平均骨密度指标(0.70 g/cm2)为临界点,低于临界点的29例患者为A组,高于临界点的另31例患者为B组。并选取同期于我院行健康体检未见明显异常的健康者60名作为健康组。比较两组患者的基础资料,并分析两组骨密度指标与IL-31水平的差异性,并分析不同骨密度指标的IL-31水平的差异性。结果研究组患者的全髋关节与腰椎L1~5的骨密度指标均低健康组,而IL-31水平则高于健康组,差异有统计学意义(P<0.05)。A患者的平均骨密度指标均低B组,而IL-31水平则高于B组,差异有统计学意义(P<0.05)。结论绝经后OP患者的血清检测中,血清IL-31水平较高,且此患者骨密度较低,两组呈现出负相关性。因此,如在临床对此类患者进行血液中的IL-31指标进行检查,可以对患者的骨密度水平进行初步的预估,帮助临床获得用药指导等。

Objective To observe the correlation between serum interleukin-31(IL-31)level and bone mineral density in postmenopausal osteoporosis patients.Methods A total of 60 patients with postmenopausal osteoporosis in our hospital(from January 2018 to December 2019)were selected as the study group,and according to the average bone mineral density index(0.70 g/cm2)of patients as the critical point,29 patients below the critical point were selected as group A,and 31 patients above the critical point were selected as group B.And 60 healthy people who had no obvious abnormality in our hospital during the same period were selected as the healthy group.The basic data of the two groups were compared,and the differences of bone mineral density index and IL-31 level between the two groups were analyzed.Results The BMD indexes of total hip and lumbar L1-5 in the study group were lower than those in the healthy group,while the level of IL-31 in the study group was higher than that in the healthy group(P<0.05).The average bone mineral density of group A was lower than that of group B,while the level of IL-31 was higher than that of group B(P<0.05).Conclusion The serum levels of IL-31 in postmenopausal osteoporosis patients are higher,and the bone mineral density is lower,which shows a negative correlation between the two groups.Therefore,if the blood IL-31 index of such patients is checked in clinic,the bone mineral density level of patients can be preliminarily estimated,and the clinical medication guidance can be obtained.