基于3D打印的个性化体模在放疗剂量验证的研究

Research on Individualized Phantom Based on 3D Printing for Radiotherapy Dose Verification

基于3D打印技术在放疗中用于剂量验证的个体化三维体模,极大限度地模拟人体的解剖结构、轮廓外形、肿瘤解剖结构及其他危及器官等组织的解剖结构,制作出合理有效的剂量验证模体。根据需要获取有效的病人数据,导入Mimics软件中进行重建需要测量的部位及其周围的人体组织、器官,并将其制作成三维空壳组件。然后3D打印进行组装、填充等效组织,从而制作出体模。用CT对体模进行扫描并将数据传至TPS系统中,将先前做好的治疗计划移植到体模上。将制作好的体模按照病人的定位信息摆放好,进行照射并测量数据。三维空壳组件是完全按照病人数据进行重建,轮廓差异不大,空壳当中填充的是CT值与空壳体积的平均CT值一致的组织辐射等效材料,CT影像数据表明体模的辐射等效性与病人实际组织近似,并且等效剂量分布符合常规治疗范围,可为调强放射治疗的精确设计提供一种可靠的剂量验证手段。

Dose verification is carried out on the individualized three-dimensional phantom based on 3D printing technology,which simulates the anatomical structure of human body,contour shape,tumor anatomical structure and other dangerous organs to the greatest extent,and produces a reasonable and effective dose validation phantom.According to the need to obtain effective patient data,import Mimics software to reconstruct the parts of the body and its surrounding tissues and organs that need to be measured,and make them into three-dimensional shell components.The 3D printing is used to assemble and fill the equivalent tissue,and then the body phantom is made.The phantom was scanned by CT and the data was transmitted to TPS system.The previously completed treatment plan was transplanted to the phantom.The phantom was placed according to the patient's location information,irradiated and measured data.The three-dimensional shell assembly is completely reconstructed according to the patient's data,and the contour difference is not significant.The shell is filled with tissue radiation equivalent material whose CT value is the same as the average CT value of the shell volume.The CT image data show that the radiation equivalence of the phantom is similar to the actual tissue of the patient,and the equivalent dose distribution conforms to the conventional treatment range.It can provide a reliable means of dose verification for the accurate design of intensity modulated radiation therapy.