摘要
The aim of this study was to formulate drug-loaded bio-lipstrips using novel bioexcipients isolated from the fruit pulp of Litchi chinesis(biomaterial L)and to explore the potentiality of lip skin as a novel translabial drug delivery system.The biomaterial,prepared by a simplified economical process and purified by hot dialysis,was subjected to various physicochemical evaluations along with spectral analysis including UV,FT-IR,Mass and ^(1)H NMR.The lipstrip formulated with the novel bioexcipients was screened for its functional properties,including filmability using a film-casting method,and bio/mucoadhesitivity using a shear-stress method,the Park and Robinson method and a rotating cylinder method.Rosiglitazone-loaded bio-lipstrips were formulated by using biomaterial L as a strip former and dextrose as a flexicizer.The formulated strips were subjected to various evaluations,including thickness,folding endurance,in-vitro release and in-vivo release.The release of rosiglitazone maleate was maintained over 24 h,which was confirmed in in-vitro and in-vivo release experiments.Our results reveal that this biopolymer possesses promising stripability as well as bio-adhesitivity.The formulated bio-lipstrips are feasible for delivering rosiglitazone maleate by translabial administration.
