肺炎支原体肺炎发生混合感染患儿预后的影响因素分析

Infl uencing factors analysis of the prognosis of children with mixed infection of mycoplasma pneumoniae pneumonia

目的探讨肺炎支原体肺炎发生混合感染患儿预后的影响因素。方法回顾性分析2017年1月—2019年12月医院住院收治的100例肺炎支原体肺炎患儿临床资料,观察患儿发生混合感染的特点及分析其预后的影响因素。结果单因素分析显示,年龄<6岁、病程≥7 d、发热持续时间≥7 d、血红蛋白<90 g/L、白蛋白<30 g/L、C-反应蛋白≥40 mg/L、降钙素原≥10μg/L、合并循环系统并发症、合并神经系统并发症、≥3个并发症、未早期使用糖皮质激素是影响肺炎支原体肺炎发生混合感染患儿预后不良的相关因素(P<0.05);多因素Logistic回归分析结果显示,发热持续时间≥7 d、C-反应蛋白≥40 mg/L、降钙素原≥10μg/L、未早期使用糖皮质激素是肺炎支原体肺炎发生混合感染患儿预后不良的独立危险因素(P<0.05)。结论发热持续时间≥7 d、C-反应蛋白≥40 mg/L、降钙素原≥10μg/L、未早期使用糖皮质激素是发生混合感染肺炎支原体肺炎患儿预后不良的独立危险因素,临床实践中应及时关注肺炎支原体患儿病情演变,施展相应临床决策。

Objective To investigate the factors affecting the prognosis of children with mixed infection of mycoplasma pneumoniae pneumonia.Methods To select 100 children with mycoplasma pneumoniae pneumonia admitted in the hospital from January 2017 to December 2019 and operated the retrospective analysis,to observe the character of mixed infection and analysis the infl uencing factors of prognosis.Results Univariate analysis showed that,age<6 yrs old,disease duration≥7 d,fever duration≥7 d,hemoglobin<90 g/L,albumin<30g/L,C-reactive protein≥40 mg/L,procalcitonin≥10μg/L,complicated circulatory system complications,complicated nervous system complications,≥3 complications,and no early use of glucocorticoid were the factors eff ect the occurrence of mixing of mycoplasma pneumonitis(P<0.05).Multivariate Logistic regression analysis result showed that,fever duration≥7 d,C-reactive protein≥40 mg/L,procalcitonin≥10μg/L,not using glucocorticoids timely were the independent risk factors for poor prognosis in children with mixed infection of mycoplasma pneumoniae pneumonia.Conclusion Fever duration≥7 d,C-reactive protein≥40 mg/L,procalcitonin≥10μg/L,not using glucocorticoids timely were the independent risk factors for poor prognosis in children with mixed infection of mycoplas ma pneumoniae pneumonia.In clinical practice,attention should be paid to the development of mycoplasma pneumoniae in time and make corresponding clinical decisions.