肠内营养联合双歧杆菌三联活菌对神经介入治疗后急性缺血性脑卒中患者二胺氧化酶及营养指标的影响

The Effect of Enteral Nutrition Combined with Live Bifidobacterium Triple Bacteria on Diamine Oxidase and Nutritional Indicators in Patients with Acute Ischemic Stroke After Neurointerventional Therapy

目的研究肠内营养联合双歧杆菌三联活菌对神经介入治疗后急性缺血性脑卒中肠道屏障功能指标和营养指标的影响。方法选取2019年10月~2020年10月在我院行神经介入治疗的96例急性缺血性脑卒中患者作为研究对象,采用随机数字表法分为对照组和观察组,各48例。对照组采用肠内营养治疗,观察组在对照组基础上联合双歧杆菌三联活菌治疗,比较两组患者NIHSS评分、肠道屏障功能指标[二胺氧化酶(DAO)、内皮素(ET)]、营养指标[白蛋白(ALB)、前白蛋白(PA)、总蛋白(TP)]、日常生活能力评分及并发症发生情况。结果两组NIHSS评分均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组DAO、ET均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组血清ALB、PA、TP均降低,但观察组高于对照组,差异有统计学意义(P<0.05);两组日常生活能力评分均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05);观察组并发症发生率为10.41%,低于对照组的12.50%,但差异无统计学意义(P>0.05)。结论肠内营养联合双歧杆菌三联活菌可降低肠道屏障功能指标水平,减少营养指标降低,促进神经功能恢复,提高患者日常生活能力,且不会增加并发症,临床应用效果良好。

Objective To study the effect of enteral nutrition combined with live bifidobacterium triple bacteria on the intestinal barrier function and nutritional indicators of acute ischemic stroke after neurointerventional therapy.Methods 96 patients with acute ischemic stroke who underwent neurointerventional therapy in our hospital from October 2019 to October 2020 were selected as the research objects,and were divided into the control group and the observation group by random number table method,with 48 cases in each group.The control group was treated with enteral nutrition,and the observation group was treated with triple live bifidobacteria on the basis of the control group.The NIHSS score,intestinal barrier function indexes[diamine oxidase(DAO),endothelin(ET)],nutritional indexes[albumin(ALB),prealbumin(PA),total protein(TP)]were compared between the two groups of patients,score of daily living ability and occurrence of complications.Results The NIHSS scores of the two groups were lower than before treatment,and the observation group was lower than the control group,the difference was statistically significant(P<0.05);The DAO and ET of the two groups were lower than before treatment,and the observation group was lower than the control group,the difference was statistically significant(P<0.05);The serum ALB,PA and TP of the two groups decreased,but the observation group was higher than the control group,the difference was statistically significant(P<0.05);The scores of daily living ability of the two groups were higher than before treatment,and the observation group was higher than the control group,the difference was statistically significant(P<0.05);The incidence of complications in the observation group was 10.41%,which was lower than 12.50%in the control group,but the difference was not statistically significant(P>0.05).Conclusion Enteral nutrition combined with bifidobacteria triple viable bacteria can reduce the level of intestinal barrier function index,reduce the decline of nutritional index,promote the recovery of neurological function,improve the patient's ability of daily living,and will not increase the complications,and the clinical application effect is good.