铜绿假单胞菌感染治疗现状

Current Therapies for Pseudomonas aeruginosa Infection

铜绿假单胞菌具有超强的本质耐药性和耐药性产生能力,因此对于感染铜绿假单胞菌的患者,多重耐药的铜绿假单胞菌的出现往往意味着抗生素在其体内的疗效变差甚至完全无效。而研发新的抗生素耗时较长且成本较高,因此寻找新的抗菌药物来代替抗生素、及寻找新的药物载体和治疗方法来增强抗菌药物的活性对多重耐药的铜绿假单胞菌感染治疗具有重要意义。该文主要回顾并总结了利用有机酸、抗菌肽、纳米粒子、噬菌体、水凝胶和细菌载体等新的抗菌药物与治疗方式在铜绿假单胞感染治疗中的一些实验室基础研究及临床研究,以期为多重耐药的铜绿假单胞菌感染治疗研究提供参考。

Pseudomonas aeruginosa has strong intrinsic antibiotic drug resistance and the ability to acquire further resistance mechanisms to multiple antibiotics.Therefore,for patients with Pseudomonas aeruginosa infection,the emergence of multidrug-resistant Pseudomonas aeruginosa often means that the efficacy of antibiotics has deteriorated or even completely ineffective.The development of new antibiotics takes a long time and is costly.Therefore,looking for new antibacterial drugs to replace antibiotics,finding new drug carriers,and new treatment methods to increase the activity of antibacterial drugs against multidrug resistant Pseudomonas aeruginosa infection treatment is of great significance.In this paper,some basic laboratory and clinical studies about using organic acids,antimicrobial peptides,nanoparticles,bacteriophages,hydrogels,bacterias in the treatment of Pseudomonas aeruginosa infection were reviewed and summarized to provide a reference for the treatment of multi-antibiotics resistant Pseudomonas aeruginosa infection.