依那普利联合环磷酰胺治疗肾病综合征患者的效果及对T淋巴细胞亚群和细胞因子的影响

The efficacy of enalapril combined with cyclophosphamide in the treatment of patients with nephrotic syndrome and its effects on T lymphocyte subsets and cytokines

目的探讨依那普利联合环磷酰胺治疗肾病综合征患者的疗效及对T淋巴细胞亚群、细胞因子的影响。方法选取2017年1月至2018年4月本院收治的120例肾病综合征患者,根据治疗方法的不同分为对照组和观察组,每组60例。对照组在常规治疗基础上加用环磷酰胺治疗,观察组在对照组基础上加用环磷酰胺联合依那普利治疗。比较两组患者临床疗效、治疗前后T淋巴细胞亚群及炎症细胞因子水平。结果治疗后,观察组患者治疗总有效率为93.33%,高于对照组的71.67%,CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)水平均高于对照组,CD8^(+)、IL-6、TNF-α水平均低于对照组,差异有统计学意义(P<0.05)。结论环磷酰胺联合依那普利治疗肾病综合征患者临床疗效显著,有利于改善机体T淋巴细胞亚群及炎症细胞因子水平。

Objective To investigate the efficacy of enalapril combined with cyclophosphamide in the treatment of patients with nephrotic syn-drome and its effects on T lymphocyte subsets and cytokines.Methods 120 patients with nephrotic syndrome admitted to our hospital from January 2017 to April 2018 were selected and divided into control group and observation group according to different treatment method,with 60 cases in each group.The control group added cyclophosphamide on the basis of conventional treatment,and the observation group added enalapril on the basis of the control group.The clinical efficacy,levels of T lymphocyte subsets and inflammatory cytokine before and after treatment were compared between the two groups.Results The total effective rate of clinical treatment in the observation group was 93.33%,which was higher than 71.67%in the con-trol group,the levels of CD3^(+),CD4^(+),CD4^(+)/CD8^(+)were higher than those of the control group and CD8^(+),IL-6,TNF-αwere lower than those in the control group,the difference was statistically significant.Conclusion Cyclophosphamide combined with enalapril in the treatment of patients with nephrotic syndrome has significant clinical effect,which is conducive to improve the body cytokines and T lymphocyte subsets indexes.