肺康复训练对老年COPD患者肺功能及炎症因子的影响

Effect of pulmonary rehabilitation training on lung function and inflammatory factors in elderly patients with COPD

目的探讨肺康复训练对老年慢性阻塞性肺病(COPD)患者肺功能及炎症因子的影响。方法回顾性分析本院2018年4月至2019年10月收治的91例老年COPD患者的临床资料,根据治疗后康复训练方式不同分为对照组(n=43)与观察组(n=48)。对照组行常规康复训练,观察组行肺康复训练,比较两组肺功能与炎症因子水平。结果康复训练12周后,两组第1秒用力肺活量/用力肺活量(FEV1/FVC)、第1秒用力呼气容积占预计值百分比(FEV1%)均高于康复训练前,C-反应蛋白(CRP)、白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)水平均低于康复训练前,且观察组低于对照组,差异有统计学意义(P<0.05)。结论老年COPD患者进行肺康复训练可有效改善其肺功能,降低炎症因子水平,值得临床推广应用。

Objective To investigate the effect of pulmonary rehabilitation training on lung function and inflammatory factors in elderly patients with chronic obstructive pulmonary disease(COPD).Methods The clinical data of 91 elderly patients with COPD admitted in our hospital from April 2018 to October 2019 were retrospectively collected and divided into the control group(n=43)and the observation group(n=48)according to different re-habilitation training methods after treatment.The control group received routine rehabilitation training,the observation group received pulmonary re-habilitation training,and the lung function indicators and inflammatory factor levels were compared between the two groups.Results After 12 weeks of rehabilitation training in both groups,forced vital capacity/forced vital capacity(FEV1/FVC)and forced expiratory volume as a percentage of predicted value(FEV1%)were higher than those before rehabilitation training,the levels of(CRP),interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)were lower than those before rehabilitation training,and the observation group was significantly lower than the control group,the difference was statistically significant(P<0.05).Conclusion Pulmonary rehabilitation training in elderly patients with COPD can effectively improve their lung function and reduce the levels of inflammatory factors,which is worthy of clinical promotion and application.