胃癌患者癌组织中精氨酸酶-1的表达及预后价值

Expression of Arg-1 in Cancer Tissues of Patients with Gastric Cancer and Its Prognostic Value

目的探讨胃癌患者癌组织中精氨酸酶-1(Arg-1)的表达及预后价值。方法通过免疫组织化学检测92例胃癌患者癌组织中Arg-1的表达,采用卡方检验比较Arg-1表达水平与临床病理参数的关系,Kaplan-Meier曲线和Log-rank检验比较高、低Arg-1表达的胃癌患者预后差异,Cox比例风险模型分析影响胃癌预后的危险因素。结果92例胃癌组织样本中71例(77.2%)Arg-1呈高表达,21例(22.8%)呈Arg-1低表达。癌组织中Arg-1高表达与患者TNM分期、分化程度、局部浸润深度、Lauren分型、淋巴结转移和远处转移相关(均P<0.05)。Arg-1高表达组1年、3年、5年无瘤生存率为73.1%、48.3%及28.0%,Arg-1低表达组1年、3年、5年无瘤生存率为82.4%、61.2%及44.0%,Arg-1高表达组无瘤生存率低于Arg-1低表达组(均P<0.01)。Arg-1高表达组1年、3年、5年总生存率为78.3%、55.3%及35.1%,Arg-1低表达组1年、3年、5年总生存率为85.2%、70.2%及46.0%,Arg-1高表达组总生存率低于Arg-1低表达组(均P<0.01)。影响胃癌患者无瘤生存率的单因素为TNMⅢ~Ⅳ期、局部浸润深度、淋巴结转移、远处转移和Arg-1高表达(均P<0.05),多因素分析显示Arg-1高表达、TNMⅢ~Ⅳ期、远处转移及淋巴结转移是无瘤生存率的独立危险因子。TNMⅢ~Ⅳ期、局部浸润深度、淋巴结转移、远处转移和Arg-1高表达为影响总生存率的单因素(均P<0.05),多因素分析显示Arg-1高表达、TNMⅢ~Ⅳ期、淋巴结转移和远处转移是影响胃癌患者总生存率的独立危险因素。结论Arg-1高表达可作为胃癌患者术后预后不良的指标。

Objective To analyze the Arginase 1(Arg-1)protein expression in gastric carcinoma tissue and its prognostic value.Methods The expression of Arg-1 in tissues of 92 cases with gastric cancer was detected by immunohistochemistry.Chi-square test was used to compare the relationship between Arg-1 expression level and clinicopathological parameters.Kaplan-Meier curve and log-rank test were used to compare the difference of prognosis between high Arg-1 expression group and low Arg-1 expression group.The Cox proportional hazard model was used to analyze the risk factors that affect the prognosis of gastric cancer.Results In gastric cancer tissues of the 92 cases,71 cases(77.2%)showed high expression of Arg-1,and 21 cases(22.8%)showed low expression of Arg-1.The high expression of Arg-1 was correlated with TNM stage,local invasion,Lauren classification,lymph node metastasis and distant metastasis(all P<0.05).The 1-year,3-year and 5-year disease-free survival rates were 73.1%,48.3%and 28.0%in the high Arg-1 expression group,while 82.4%,61.2%and 44.0%in the low Arg-1 expression group,respectively.The tumor-free survival rate of the high Arg-1 expression group was significantly lower than that of the low Arg-1 expression group(P<0.01).The 1-year,3-year and 5-year overall survival rates were 78.3%,55.3%and 35.1%in the high Arg-1 expression group,while 85.2%,70.2%and 46.0%in the low Arg-1 expression group,respectively.The overall survival rate of the high Arg-1 expression group was significantly lower than that of the low Arg-1 expression group(P<0.01).TNM stageⅢ-Ⅳ,depth of tumor invasion,lymph node metastasis,distant metastasis and high Arg-1 expression were the single factors influencing the tumor-free survival rate of gastric cancer patients(P<0.05).Multivariate analysis showed that the high expression of Arg-1,TNMⅢ-Ⅳstage,lymph node metastasis and distant metastasis were independent risk factors for tumor-free survival rate of gastric cancer patients.TNMⅢ-Ⅳstage,local invasion depth,lymph node metastasis,distant metastasis and high Arg-1 expression were the single factors influencing the overall survival rate(P<0.05).Multivariate analysis showed that high Arg-1 expression,TNMⅢ-Ⅳstage,lymph node metastasis and distant metastasis were independent risk factors for overall survival rate of gastric cancer patients.Conclusion The high expression of Arg-1 can be used as an indicator of poor prognosis in patients with gastric cancer.