山楂消脂胶囊对高血压并颈动脉硬化患者的临床作用

Shanzha Xiaozhi Capslue for hypertensive patients with carotid atherosclerosis

目的观察山楂消脂胶囊治疗原发性高血压并颈动脉硬化(痰瘀互结证)的临床疗效。方法将79例符合标准的患者随机分为观察组39例和对照组40例,对照组给予常规药物治疗,观察组在对照组基础上加服山楂消脂胶囊,疗程均为6个月。观察两组治疗前后中医证候疗效、颈动脉内膜中层厚度(IMT)、臂踝脉搏波传导速度(baPWV)和踝臂指数(ABI)、同型半胱氨酸(HCY)和脂蛋白相关磷脂酶A2(Lp⁃PLA2)及安全性指标变化情况。结果中医证候疗效方面,观察组总有效率87.18%,优于对照组67.50%(P<0.05);治疗后,两组baPWV、ABI和HCY均有改善(P<0.01),观察组均优于对照组(P<0.01);对照组IMT、Lp⁃PLA2改善不明显(P>0.05),观察组有改善(P<0.01),优于对照组(P<0.05)。安全性评价方面,两组肝肾功能及肌酸激酶均未出现明显异常。结论山楂消脂胶囊对原发性高血压并颈动脉硬化(痰瘀互结证)的中医证候及颈动脉硬化相关指标有显著疗效,使用安全。

Objective To observe the effect of Shanzha Xiaozhi Capslue on essential hypertension with carotid arteriosclerosis(the stasis⁃phlegm combined pattern from the perspective of TCM).Methods According to the inclusion criteria,a total of 79 patients with essential hypertension combined with carotid atherosclerosis were randomly assigned to treatment group(n=39)and control group(n=40).All patients received routine treatment and those in the treatment group were additionally given Shanzha Xiaozhi Capslue for 6 months.The change of TCM pattern,the change of carotid intima media thickness(IMT),brachial⁃ankle pulse wave velocity(baPWV),ankle⁃brachial index(ABI),homocysteine(HCY),lipoprotein associated phospholipase A2(Lp⁃PLA2)and safety were observed.Results After treatment,the total effective rate for TCM pattern was 87.18%in the treatment group and 67.50%in the control group(P<0.05);The levels of baPWV,ABI and HCY in the two groups were significantly improved(P<0.01),and those in the treatment group were significantly improved(P<0.01).The levels of LMT and Lp⁃PLA2 were not significantly improved in the control group(P>0.05),but were significantly improved in the treatment group(P<0.01),which was better than the control group(P<0.05).In terms of safety,there were no significant abnormalities in liver function,renal function,or creatine kinase in the two groups.Conclusion Shanzha Xiaozhi Capslue was effective and safe for essential hypertension combined with carotid arteriosclerosis.