摘要
[Objectives]The differences in secondary metabolites of Herba Polygoni Chinensis from Guangxi were analyzed,in order to find flavonoids which can antagonize liver injury and provide a basis for the quality evaluation of Herba Polygoni Chinensis.[Methods]UPLC-MS was used to analyze the secondary metabolites of Herba Polygoni Chinensis,and emphasis was placed on flavonoids.[Results]Flavonoids were abundant in the secondary metabolites of Herba Polygoni Chinensis.Quercitrin,catechin gallate,epicatechin gallate,hyperoside and so on were screened as the components with high content and antagonistic effect on liver injury.[Conclusions]Quercitrin was the flavonoid compound with the highest content among the three origins.It is stable and has a good protective effect on liver,which is representative.Quercitrin can be considered as the target component to be used as an important index for quality evaluation of Herba Polygoni Chinensis.
基金
Development of Huotanmu Capsules,a New Zhuang Drug for Hepatitis B(20183046-1)
Collaborative Innovation Center of Zhuang and Yao Ethnic Medicine(Gui Jiao Ke Yan[2013]20)
Guangxi Key Laboratory of Zhuang and Yao Ethnic Medicine(Gui Ke Ji Zi[2014]32)
Key Discipline of Guangxi:Science of Zhuang Medicine(Gui Jiao Ke Yan[2013]16)
First-class Discipline of Guangxi:Ethnopharmacology(Gui Jiao Ke Yan[2018]12).