摘要
[Objectives]To study the therapeutic effect and mechanism of Qianjin Lotion on eczema in mice.[Methods]A mouse eczema model was established by the 2,4-dinitrochlorobenzene method.The indicators of mouse ear swelling degree,the number of dermal inflammatory cells,the number of body licking reactions,the IL-2 and TNF-αcontent in serum were detected to explore the therapeutic effect and mechanism of Qianjin Lotion on eczema in mice.[Results]Qianjin Lotion can effectively eliminate skin inflammation,reduce the degree of auricle swelling,reduce the number of dermal inflammation cells,reduce the number of body licking reactions,and reduce the IL-2 and TNF-αcontent in serum.[Conclusions]Qianjin Lotion can alleviate the symptoms of eczema in mice,reduce inflammatory factors.Combined with oral administration of Qianjin granules,it can treat eczema and achieve good effects.
基金
Project of National Natural Science Foundation of China(81274026)
Program of Guangxi University of Chinese Medicine(2018MS022)
Project for Improving Basic Research Ability of Middle Aged and Young Teachers in Colleges and Universities of Guangxi in 2020(2020KY07036)
Open Program of Key Laboratory of Guangxi Zhuang and Yao Medicine(GXZYKF2019-17)
First-class Discipline Project of Guangxi University of Chinese Medicine(2019XK102)
Project of Key Laboratory of Guangxi Zhuang and Yao Medicine(Gui Ke Ji Zi[2014]No.32).
