炎症因子在HIE中的作用及诊治应用

The role of inflammatory cytokines in HIE and its application in diagnosis and treatment

缺氧缺血性脑病(hypoxic-ischemic encephalopathy, HIE)是由围生期窒息所致的新生儿脑病,其死亡率和致残率均极高。亚低温是目前唯一有效的治疗方法,但其治疗时间窗窄,且部分患儿即使经过治疗后仍有后遗症。尽早诊断有益于HIE的治疗,减轻其危害。临床上诊断HIE主要依靠临床表现和颅脑磁共振成像检查,往往存在漏诊或延误诊断的情况。近年来,炎症被认为是HIE的重要发病机制,可能有助于HIE的诊治。本文就炎症因子在新生儿HIE中的作用及其在临床诊治中的应用进展进行综述。

Hypoxic-ischemic encephalopathy(HIE) is a neonatal encephalopathy caused by perinatal asphyxia with extremely high mortality and disability rate. Currently, hypothermia is the only approved therapy for neonatal HIE in the clinic. However, the therapeutic window is narrow, and there are some infants survive with a series of impairments despite hypothermia treatment. Early diagnosis is beneficial to the treatment of HIE. The clinical diagnosis of HIE mainly depends on clinical manifestations and brain magnetic resonance imaging, and there are often cases of missed diagnosis or delayed diagnosis. In recent years, inflammation is considered to be an important pathogenesis of HIE, which may be helpful to its diagnosis and treatment. This review discusses the role of inflammatory cytokines in neonatal HIE and its application in clinical diagnosis and treatment.