应关注2型糖尿病患者的骨脆性变化

Attention is needed to bone fragility in patients with type 2 diabetes mellitus

近年来,2型糖尿病(T2DM)患者的骨脆性变化日益受到重视。即使在骨密度正常时,T2DM患者的骨折风险仍可增加。T2DM患者骨脆性增加的影响因素众多,病理生理学机制较为复杂。此外,常用降糖药物对骨代谢的影响也各不相同。因此,关注T2DM患者的骨脆性变化,综合管理骨折风险,合理选择降糖药物治疗,是临床上必须引起重视的问题。

In recent years,the changes of bone fragility in patients with type 2 diabetes mellitus(T2DM)has attracted much attention.T2DM is associated with an increased risk of bone fracture even in the patients with normal bone mineral density.There are many factors contributing to the increased bone fragility in patients with T2DM,and its pathophysiological mechanisms are relatively complicated.Moreover,each antidiabetic medication also has different effect on bone metabolism.Therefore,attention should be paid to the changes of bone fragility,comprehensive management of fracture risk,and rational selection of antidiabetic drugs in patients with T2DM.