维生素D受体基因多态性与亚洲绝经后女性骨密度相关性的荟萃分析

A meta-analysis of the association between vitamin D receptor gene polymorphism and bone mineral density in Asian postmenopausal women

目的旨在荟萃分析维生素D受体基因多态性与亚洲绝经后女性骨密度的相关性。方法计算机检索PubMed、Embase、Web of Science、中国知网(CNKI)等数据库,时间截止2020年12月,筛选符合纳入标准的研究。运用Clark等报道的方法来评价纳入文献质量,用RevMan 5.3软件进行统计学分析。结果最终纳入15项研究,包括3881个研究对象,均为亚洲绝经后女性。荟萃分析结果显示,维生素D受体位点ApaI、FokI、TaqI基因多态性与腰椎骨密度相关,ApaI基因aa基因型的骨密度高于AA基因型,FokI基因FF基因型的骨密度高于ff基因型,TaqI基因Tt基因型的骨密度高于TT基因型。维生素D受体位点ApaI、FokI基因多态性与股骨颈骨密度相关,ApaI基因Aa基因型的骨密度高于AA基因型,FokI基因FF基因型的骨密度高于ff基因型。结论维生素D受体位点ApaI、FokI基因多态性既与腰椎骨密度相关,也与股骨颈骨密度相关,而维生素D受体位点TaqI基因多态性与腰椎骨密度相关。

Objective To analyze the correlation between vitamin D receptor gene polymorphism and bone mineral density in Asian postmenopausal women.Methods PubMed,EMBASE,Web of Science,CNKI and other databases were searched until December 2020,to find researches that met the inclusion criteria.The method reported by Clark et al.was used to evaluate the quality of the included literatures,and RevMan 5.3 software was used for statistical analysis.Results Finally,15 studies were included,including 3881 subjects.All were Asian postmenopausal women.Meta-analysis showed that vitamin D receptor ApaI,FokI,TaqI gene polymorphisms were associated with lumbar spine bone density.BMD of aa genotype was higher than that of AA genotype in ApaI,BMD of FF genotype was higher than that of ff genotype in FokI,and BMD of Tt genotype was higher than that of TT genotype in TaqI.Vitamin D receptor ApaI and FokI gene polymorphisms were related to femoral neck bone mineral density.the AA genotype had higher BMD than the Aa genotype in ApaI,and the FF genotype had higher BMD than the ff genotype in FokI.Conclusion The ApaI and FokI gene polymorphisms of vitamin D receptor are not only related to the bone mineral density of the lumbar spine,but also to the bone mineral density of the femoral neck,and the vitamin D receptor TaqI gene polymorphism is related to the bone density of the lumbar spine.