尿酸转运蛋白及其相互作用蛋白在尿酸代谢中的作用研究进展

Research progress on the role of uric transporters and its protein interaction in uric acid metabolism

尿酸的重吸收和排泄依赖尿酸转运蛋白的作用,人体内尿酸转运蛋白数目众多,如葡萄糖转运蛋白9(GLUT9)、有机阴离子转运体1(OAT1)、尿酸盐转运蛋白1(URAT1)等,但单一尿酸转运蛋白的错义翻译很少直接导致高尿酸血症的发生,尿酸转运蛋白的相互作用蛋白,如跨膜整合蛋白2B(ITM2B)、乙醛脱氢酶16家族A1(ALDH16A1)、PDZ结构域蛋白1(PDZK1)等在高尿酸血症的发生、发展过程中同样有着举足轻重的地位。因此不仅仅研究单一尿酸转运蛋白的错义翻译,同时关注尿酸转运蛋白及其相互作用蛋白在尿酸代谢中的作用,有利于更加深入了解高尿酸血症的发病机制。

The reabsorption and excretion of uric acid depends on the action of uric acid transporter.There are many uric acid transporters in the human body,such as GLUT9,OAT1,URAT1,etc.However,the missense translation of a single uric acid transporter rarely directly leads to the occurrence of hyperuricemia.The interacting proteins of transporters,such as ITM2B,ALDH16A1,PDZK1,etc.also play a pivotal role in the occurrence and development of hyperuricemia.Therefore,not only studying the missense translation of a single uric acid transporter,but also paying attention to the role of uric acid transporter and its interacting proteins in uric acid metabolism will help to understand the pathogenesis of hyperuricemia.