WISP1与骨质疏松症关系的研究进展

Research progress on the relationship between WISP1 and osteoporosis

骨质疏松症(osteoporosis,OP)的病因主要为由成骨细胞(osteoblast,OB)介导的骨形成与由破骨细胞(osteoclast,OC)介导的骨吸收之间的平衡失调,骨形成/骨吸收比例降低,导致进行性骨丢失。Wnt1诱导信号通路蛋白1(Wnt1-inducible signaling pathway protein 1,WISP1)是调控OB与OC分化及活性的关键调节因子,在骨骼发育及骨折愈合过程的各阶段表达,并通过诱导干细胞向OB分化、提高OB活性及抑制OC分化与形成等方式促进骨形成、抑制骨吸收,从而提高骨量。WISP1在骨骼系统的促进成骨作用使其成为OP潜在的治疗靶点。

The pathogenesis of osteoporosis is the imbalance between bone formation mediated by osteoblasts and bone resorption mediated by osteoclasts,which leading to continuous bone loss.Wnt1-inducible signaling pathway protein 1(WISP1)is a key regulator regulating the differentiation and activity of osteoblasts and osteoclasts.It is expressed at various stages of bone development and fracture healing,and promotes bone formation,inhibits bone resorption and increases bone mass by inducing stem cells to differentiate into osteoblasts,enhancing osteoblast activity and inhibiting osteoclast differentiation.The osteogenic effect of WISP1 in the skeletal system makes it a potential therapeutic target for osteoporosis.