某院64例替加环素临床应用回顾性分析

Retrospective Analysis of Clinical Application of Tigecycline in 64 Hospitalized Patients

目的:对某院替加环素临床用药及管理情况进行评价。方法:应用回顾性研究方法,根据《替加环素临床应用评价细则》,对某院2018年替加环素的临床应用的有效性、安全性与合理性进行评价。结果:收集到相关病例共64份。替加环素用药前微生物送检率为98.4%,联合用药率为100%,临床应用评价得分(84.77±26.03)分;临床应用不合理43例(67.19%),主要表现为特殊使用级抗菌药物会诊不规范37例(57.81%),适应证不适宜5例(7.81%),用法用量不适宜10例(15.63%),使用抗菌药物前未送病原学检查1例(1.56%)。使用替加环素病例的临床有效率为56.25%;发生不良反应5例(7.81%)。替加环素给药剂量超说明书23例(35.94%)。结论:某院住院患者使用替加环素不合理率较高,主要表现为适应证不适宜、用法用量不适宜及特殊使用级抗菌药物处方与会诊管理不规范。替加环素合理用药水平有待提高。

Objective:To evaluate the clinical medication and management of tigecycline in a hospital.Methods:A retrospective study method was used to evaluate the rationality of the clinical application of tigecycline in the hospital in 2018 according to detailed rules for evaluation of clinical application of tigecycline.Results:A total of 64 cases were collected.The rate of microbial examination prior to the administration of tigecycline was 98.4%.The combined rate of tigecycline was 100%.The clinical application evaluation score of tigecycline was(84.77±26.03)points;There were 43 cases(67.19%)with unreasonable clinical application of tigecycline,the main manifestations were 37 cases(57.81%)with nonstandard consultation of special use antibiotics,5 cases(7.81%)with unsuitable indications,and 10 cases(15.63%)with inappropriate usage and dosage,and 1 case with no etiological examination before the use of antibiotics.The clinical effective rate of tigecycline was 56.25%;Adverse drug reactions occurred in 5 cases.23 cases(35.94%)of off-label drug use of tigecycline.Conclusion:The unreasonable rate of using tigecycline among inpatients in the hospital was high,which mainly reflected in inappropriate indications,inappropriate usage and dosage,and nonstandard prescription and consultation management of Specialized antibacterial drugs.The level of rational use of tigecycline shoud be improved.