摘要
综述了由拜耳作物科学公司开发的新型双酰胺类杀虫剂四唑虫酰胺(Tetraniliprole)的合成方法,主要包括缩合法、胺解法和环化法等3种方法,且对这些方法所涉及的关键中间体的合成也进行了简要概述。其中,缩合法,特别是以关键中间体N,3-二甲基-2-氨基-5-氰基苯甲酰胺和1-(3-氯吡啶-2-基)-3-(5-三氟甲基-2H-四氮唑-2-亚甲基)吡唑-5-甲酸在碱和甲磺酰氯作用下直接合成四唑虫酰胺的合成路线,具有原料易得、产率高和易于操作等优点,可能是目前制备四唑虫酰胺的最佳合成工艺。
Synthetic methods of tetraniliprole developed by Bayer CropScience as the new bisamide insecticide were reviewed,including three methods:condensation,aminolysis and cyclization,and the synthesis of key intermediates involved in these methods was also briefly summarized.Among them,the condensation method,especially the route of the key intermediates N,3-dimethyl-2-amino-5-cyanobenzamide and 1-(3-chloropyridin-2-yl)-3-(5-Trifluoromethyl-2H-tetrazolium-2-methylene)pyrazole-5-carboxylic acid under the action of alkali and methanesulfonyl chloride,had the advantages of easy availability of raw materials,high yield and easy operation,which may be the best synthetic process for preparing tetrazolidene at present.
作者
党铭铭
郭永艳
田雁飞
柳爱平
刘卫东
刘民华
DANG Ming-ming;CUYong-yan;TIAN Yan-fei;LIU Ai-ping;LIU Wei-dong;LIU Min-hua(Department of Resources and Environment,Hunan Nonferrous Metals Vocational and Technical College,Zhurzhou 412000,China;National Engineering Research Center for Agrochemicals,Hunan Research lnstitute of Chemical Industry Co.,Ltd.,Changsha 410014,China;Hunan Province Key Laboratory for Agrochemicals,Changsha 410014,China)
出处
《化学试剂》
CAS
北大核心
2021年第8期1070-1076,共7页
Chemical Reagents
基金
2018年湖南省有色金属管理局直属单位转型发展项目
国家自然科学基金资助项目(21672057)
“十三·五”国家重点研发计划项目(2016YFD0300708)
湖南海利新材料科技创新创业团队项目。