血管紧张素转化酶(ACE)基因I/D多态性与运动能力关系

The relationship between Ang.Iotensin-converting enzyme gene I/D polymorphism and athletic ability

对比优秀有氧耐力运动员与普通健康大学生的血管紧张素转化酶(Angiotensin-converting enzyme,ACE)基因型,探讨ACE基因I/D多态性与心脏结构和运动能力的关系.结果:1)优秀有氧耐力运动员(EA)组和普通健康大学生(NC)组受试者的基因型分布符合Hardy-Weinberg平衡(P>0.05),结果具有一定的群体代表性;2)EA组基因频率(D为0.350;I为0.650)与NC组(D为0.545,I为0.455)具有差异,EA组基因频率I基因频率显著偏高;3)将EA组分为Ⅱ,DD和ID三个基因型,结果显示左室质量指数(left ventricular mass/body surface area,LVM/BSA)在Ⅱ与DD基因型之间具有显著差异(P<0.05);无氧运动后血乳酸峰值在基因型Ⅱ与DD,ID与DD之间均有显著性差异(P<0.05),基因型Ⅱ与ID之间无显著性差异;在体脂比例方面,基因型Ⅱ与ID,DD的差异性均显著(P<0.05).结论:优秀耐力运动员等位基因I频率较高.不同基因型的耐力运动员,左室质量指数和体脂比指标,Ⅱ显著低于ID和DD.这提示等位基因D对心肌肥大的敏感性更强,等位基因I对糖酵解供能和脂代谢调控敏感性更强.

Compared Angiotensin-converting enzyme(ACE)genotypes of elite aerobic endurance athletes with normal healthy college students,and discussed the relationship between ACE gene I/D polymorphism and athletic ability.Results:1)The genotype distribution of elite aerobic endurance athletes(EA)and normal healthy college students(NC)was in accordance with Hardy-Weinberg equilibrium(P>0.05),indicating that the experimental results have a certain representativeness of the population.2)Gene frequency of EA group(D is 0.350,I is 0.650)was different from that of NC group(D is 0.545,I is 0.455).The gene frequency of I gene was significantly higher in EA group.3)EA group was divided intoⅡ,DD and ID genotypes,LVM/BSA had significant difference betweenⅡand DD genotypes(P<0.05);there were significant differences betweenⅡand DD,ID and DD in the blood lactate peak after anaerobic exercise(P<0.05),but there was no significant difference betweenⅡand ID;in the aspect of body fat percentage,the differences betweenⅡand ID,DD were significant(P<0.05).Conclusion:the frequency of allele I gene was higher in elite endurance athletes.In different genotypes endurance athletes,the left ventricular mass index and body fat ratio index,Ⅱwas significantly lower than ID and DD.It suggests that allele D gene is more sensitive to myocardial hypertrophy,and allele I gene is more sensitive to glycolysis energy supply and lipid metabolism regulation.