摘要
Since chloroquine(CQ)and hydroxychloroquine(HCQ)can inhibit the invasion and proliferation of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)in cultured cells,the repurposing of these antimalarial drugs was considered a promising strategy for treatment and prevention of coronavirus disease(COVID-19).However,despite promising preliminary findings,many clinical trials showed neither significant therapeutic nor prophylactic benefits of CQ and HCQ against COVID-19.Here,we aim to answer the question of why these drugs are not effective against the disease by examining the cellular working mechanisms of CQ and HCQ in prevention of SARS-CoV-2 infections.
基金
supported by a Young Investigator Grant from the Human Frontier Science Program(HFSP
RGY0080/2018)
a Vidi grant from the Netherlands Organization for Scientific Research(NWO-ALW VIDI 864.14.001)
funding from the European Research Council(ERC)under the European Union’s Horizon 2020 research and innovation programme(grant agreement no.862137).
