摘要
Five new sesquiterpenoids(1-5),chloranholides A-E,along with three known compounds(6-8),were isolated from the whole plants of Chloranthus holostegius.Their structures were elucidated using the spectroscopic methods(IR,UV,HR-ESI-MS,ID and 2D NMR),and their absolute configurations were determined by the X-ray crystallography and ECD calculation.Compounds 1-8 were evaluated for their anti-inflammatory effects on LPS-induced RAW 264.7 macrophage cells.Especially,compound 4 exhibited the most significant anti-inflammatory activity with the secretion levels of TNF-α and IL-6 at 15.52%and 5.98%,respectively,better than that of dexamethasone.
基金
the National Key R&D Program of China(No.2017YFC1703800)
the National Natural Science Foundation of China(Nos.81973190,81803376)
the Guangdong Basic and Applied Basic Research Foundation(No.2020B1515020033)
the Natural Science Foundation of Guangdong Province(No.2018B030311020)
the Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program(No.2017BT01Y036)
the high performance public computing service platform of Jinan University.
