乳杆菌抑制幽门螺杆菌感染的分子机制

Molecular mechanisms of Lactobacilli against Helicobacter pylori infection

乳杆菌具有调节胃肠道菌群、改善胃肠道功能的益生作用。幽门螺杆菌是定植于胃黏膜的革兰阴性致病菌,可诱发胃癌。目前,幽门螺杆菌根除率逐年下降,临床上开始尝试应用嗜酸乳杆菌、鼠李糖乳杆菌和加氏乳杆菌等乳杆菌联合抗生素治疗幽门螺杆菌。然而不同临床研究结论有差异,临床疗效仍有待提升。该文通过综述乳杆菌治疗幽门螺杆菌的临床研究,进一步探讨其抑制幽门螺杆菌感染的分子机制,包括细菌素的直接杀菌、黏附抑制、胃肠道微生物群调节、炎症抑制等,为筛选理想乳杆菌菌株,提高幽门螺杆菌临床疗效提供新方案。

Lactobacilli have the probiotic effects of regulating gastrointestinal microbiota and improving gastrointestinal function.Helicobacter pylori(Hp)is a gram-negative pathogen colonizing in gastric mucosa and can induce gastric cancer,while the eradication rate of Hp is decreasing year by year.In recent years,Lactobacillus acidophilus,Lactobacillus rhamnosus,Lactobacillus gasseri and other Lactobacilli combined with antibiotics are applied to treat Hp infection.However,results of various clinical studies are inconsistent,and the eradication rate of Hp still needs to be improved.This article reviews the clinical researches about the effects of Lactobacilli on the eradication of Hp,and further discusses the molecular mechanisms of Lactobacilli against Hp infection including direct killing effects of bacteriocin,adhesion inhibition,gastrointestinal microbiota regulation and inflammation inhibition,aiming to provide a new approach for screening optimal Lactobacilli strains and therefore to improve the clinical therapeutic effect of Hp infection.