氟康唑联合咪康唑治疗顽固性霉菌性阴道炎的临床效果

Clinical effect of fluconazole combined with miconazole in the treatment of refractory mycotic vaginitis

目的分析氟康唑联合咪康唑治疗顽固性霉菌性阴道炎的临床效果。方法选取2018年1月至2020年3月我院收治的88例顽固性霉菌性阴道炎患者,按奇偶数分组法将其分为对照组(44例,氟康唑)和观察组(44例,氟康唑+咪康唑)。比较两组的临床效果、临床症状改善时间、阴道健康状态、不良反应发生情况及疾病复发情况。结果观察组的治疗总有效率为97.73%,高于对照组的77.27%(P<0.05)。观察组的外阴瘙痒、外阴红斑、白带异常、黏膜充血改善时间均短于对照组(P<0.05)。治疗后,两组的阴道弹性、阴道湿润、pH、阴道黏膜出血、阴道分泌物评分均升高,且观察组高于对照组(P<0.05)。两组的不良反应总发生率比较,差异无统计学意义(P>0.05)。治疗后6个月,观察组的疾病复发率为2.27%,低于对照组的15.91%(P<0.05)。结论氟康唑联合咪康唑治疗顽固性霉菌性阴道炎的临床效果显著,可在短时间内改善患者的各项临床症状及阴道健康状态,且安全性较高、复发率较低,值得临床推广应用。

Objective To analyze the clinical effect of fluconazole combined with miconazole in the treatment of refractory mycotic vaginitis.Methods A total of 88 patients with refractory mycotic vaginitis admitted in our hospital from January 2018 to March 2020 were selected and divided into control group(44 cases,fluconazole)and observation group(44 cases,fluconazole+miconazole)according to odd-even grouping method.The clinical effect,improvement time of clinical symptoms,vaginal health state,adverse reactions and disease recurrence were compared between the two groups.Results The total effective rate of treatment in the observation group was 97.73%,which was higher than 77.27%in the control group(P<0.05).The improvement time of vulva pruritus,vulva erythema,abnormal leucorrhea and mucosal congestion in the observation group were shorter than those in the control group(P<0.05).After treatment,the scores of vaginal elasticity,vaginal moisture,pH,vaginal mucosal bleeding and vaginal secretion in the two groups increased,and those in the observation group were higher than the control group(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).At 6 months after treatment,the disease recurrence rate in the observation group was 2.27%,which was lower than 15.91%in the control group(P<0.05).Conclusion Fluconazole combined with miconazole in the treatment of refractory mycotic vaginitis has a significant clinical effect,it can improve the various clinical symptoms and vaginal health state of patients in a short time,and has higher safety and lower recurrence rate,which is worthy of clinical promotion and application.