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酒精性肝炎发病机制的研究进展 被引量:6

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摘要 酒精性肝炎(alcoholic hepatitis,AH)是一种急性炎症性肝病,在短期和长期内都有很高的发病率和死亡率[1]。迄今为止,AH的确切发病机制尚待明确。目前的研究主要涉及肠黏膜屏障的破坏、氧化应激、炎症、细菌移位、细胞死亡和再生障碍等[2-3]。
出处 《中国临床医生杂志》 2021年第8期907-911,共5页 Chinese Journal For Clinicians
基金 国家青年自然科学基金项目(8170030364)。
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  • 1Asher Zaman Safi,Yasir Waheed,Joharia Sadat,Solat-Ul-Islam,Sadia Salahuddin,Umar Saeed,Muhammad Ashraf.Molecular study of HCV detection,genotypes and their routes of transmission in North West Frontier Province,Pakistan[J].Asian Pacific Journal of Tropical Biomedicine,2012,2(7):532-536. 被引量:5
  • 2Natalia A Osna,Terrence M Donohue Jr.Implication of altered proteasome function in alcoholic liverinjury[J].World Journal of Gastroenterology,2007,13(37):4931-4937. 被引量:10
  • 3Yue‐ShengWu,Katja S.Salmela,Charles S.Lieber.Microsomal Acetaldehyde Oxidation is Negligible in the Presence of Ethanol[J]. Alcoholism: Clinical and Experimental Research . 2006 (5)
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  • 6Praveen Sharma,Ashish Kumar,Barjesh Chander Sharma,Shiv Kumar Sarin.Infliximab monotherapy for severe alcoholic hepatitis and predictors of survival: An open label trial[J].Journal of Hepatology.2009(3)
  • 7Marlene Dominguez,Rosa Miquel,Jordi Colmenero,Montserrat Moreno,Joan–Carles García–Pagán,Jaime Bosch,Vicente Arroyo,Pere Ginès,Juan Caballería,Ramón Bataller.Hepatic Expression of CXC Chemokines Predicts Portal Hypertension and Survival in Patients With Alcoholic Hepatitis[J].Gastroenterology.2009(5)
  • 8Saroj Nepal,Pil-Hoon Park.Activation of autophagy by globular adiponectin attenuates ethanol-induced apoptosis in HepG2 cells: Involvement of AMPK/FoxO3A axis[J].BBA - Molecular Cell Research.2013(10)
  • 9Isaac S. Chan,Cynthia D. Guy,Mariana V. Machado,Abigail Wank,Vishnu Kadiyala,Gregory Michelotti,Steve Choi,Marzena Swiderska‐Syn,Gamze Karaca,Thiago A. Pereira,Michele T. Yip‐Schneider,C. Max Schmidt,Anna Mae Diehl.Alcohol Activates the Hedgehog Pathway and Induces Related Procarcinogenic Processes in the Alcohol‐Preferring Rat Model of Hepatocarcinogenesis[J].Alcohol Clin Exp Res.2014(3)
  • 10Lili Yang,Defeng Wu,Xiaodong Wang,Arthur I. Cederbaum.Cytochrome P4502E1, oxidative stress, JNK, and autophagy in acute alcohol-induced fatty liver[J].Free Radical Biology and Medicine.2012(5)

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