绿豆皮对高脂饲料联合链脲佐菌素诱导的糖尿病小鼠糖脂代谢的改善作用

Improvement of Mung Bean Seed-coat on Glucose/Lipid Metabolism in Diabetic Mice Induced by High-fat Diet Combined with Streptozotocin

通过建立的高脂饲养联合链脲佐菌素诱导的糖尿病小鼠模型,探究绿豆皮对糖尿病小鼠糖脂代谢的影响。动物实验结果表明,将6%的绿豆皮添加到高脂饲料中,通过连续8周的干预,与模型组糖尿病小鼠相比,干预组小鼠的血糖、血脂和糖化血清蛋白水平显著降低(P<0.05),胰岛素分泌水平显著升高(P<0.05),葡萄糖耐量显著改善(P<0.05)。通过对肝组织和胰腺组织进行病理学观察发现,补充绿豆皮可有效缓解糖尿病小鼠的肝和胰腺组织损伤。绿豆皮对糖尿病小鼠具有显著的改善作用,为扩大绿豆皮的应用以及辅助降糖功能食品的开发具有重要的意义。

The effects of mung bean seed-coat on glucose and lipid metabolism in diabetic mice by establishing a high-fat feeding combined with streptozotocin-induced diabetic mouse model was investigated.The results showed that,compared with the diabetic mice in the model group,a high-fat diet supplemented with mung bean seed-coat(6%)for 8 weeks could significantly reduced the blood glucose,blood lipid and glycated serum protein levels of mice in the intervention group(P<0.05).Moreover,the insulin secretion levels and glucose tolerance were significantly increased and improved by mung bean seed-coat supplementation(P<0.05),respectively.In addition,the hepatic and pancreatic histopathological observations showed that mung bean seed-coat supplementation could effectively relieve liver and pancreatic tissue damage and increase the number of isletsβcells.The significant improvement effects of mung bean seed-coat on diabetic mice are of great practical significance for expanding its application and the development of auxiliary foods for reducing blood sugar.