摘要
高糖对机体健康具有较大影响。血糖浓度偏高会引起机体氧化应激,而信号通路调控紊乱是高糖引起氧化应激的主要原因之一。随着糖尿病患病率的持续增高,由高糖引起的相关疾病广受关注。目前有关高糖引起的氧化应激及其相关细胞信号通路在各系统疾病中的研究尚未见报道。本文从细胞类型出发,结合糖尿病及其相关并发症给机体不同系统带来的影响,对高糖引起的、与氧化应激相关的细胞信号通路逐一分析比较,旨在为相关疾病的研究提供理论参考。
High glucose has a greater impact on the body's health.High blood glucose concentrations can cause oxidative stress in the body,and has a wide range of effects,which mainly affects the body's circulatory system,urinary system,and nervous system.Disturbances in signal pathway regulation are one of the main causes of oxidative stress caused by high glucose.With the increasing of prevalence of diabetes,related diseases caused by high glucose have received more and more attention and research,but the study of oxidative stress caused by high glucose and related cell signaling pathways in various system diseases have no comprehensive report.This article firstly summarized different cell types commonly used in the research on different system diseases caused by high glucose and combined the effects of diabetes and its series of complications in different systems of the body.Meanwhile,statistically analyzing the research focued of relevant cell signaling pathways in various system diseases in the past five years.Then by analyzing and comparing the signal pathways related to oxidative stress caused by high glucose,and deriving the internal connections between the pathways,it provided a theoretical reference for the study of oxidative stress related diseases caused by high sugar.
作者
唐柳欢
袁媛
崔校基
蔡洁
梁盈
Tang Liuhuan;Yuan Yuan;Cui Xiaoji;Cai Jie;Liang Ying(School of Food Science and Engineering,Central South University of Forestry and Technology,National Engineering Laboratory for Rice and Byproduct Deep Processing,Changsha 410004;Hunan Traditional Chinese Medical College,Zhuzhou 412012,Hunan)
出处
《中国食品学报》
EI
CAS
CSCD
北大核心
2021年第7期338-348,共11页
Journal of Chinese Institute Of Food Science and Technology
基金
湖南省自然科学基金面上项目(2020JJ4138)
国家自然科学基金面上项目(31571874)
湖湘青年科技创新人才项目(2016RS3033)
湖南省教育厅科学研究项目(18A160)。
关键词
高糖
氧化应激
信号通路
细胞
系统疾病
high glucose
oxidative stress
signaling pathway
cell
systemic disease
