摘要
The progression of cells from a normal differentiated state in which the rates of proliferation and apoptosis are in check,to a tumorigenic and metastatic state where these rates are imbalanced,likely involves the accumulation of mutations in multiple genes,and the evolution and clonal selection of more aggressive phenotypes.These events are associated with changes in the expression of numerous gene products including the transient receptor potential(TRP)proteins.
基金
The author is thankful to Prof.Robert Getzenberg for his comments and helpful discussions.
