CGRP、EGF及TGF-β1与创伤性骨折患者应激状态及骨折愈合的关系

The relationship of CGRP,EGF and TGF⁃β1 with stress state and fracture healing in pa⁃tients with traumatic fracture

目的探讨降钙素基因相关肽(CGRP)、表皮生长因子(EGF)及转化生长因子-β1(TGF-β1)与创伤性骨折患者应激状态、骨折愈合的关系研究。方法选取2017年5月-2019年5月在本院进行治疗的116例创伤性骨折患者设为观察组根据预后分为愈合良好组(n=62),愈合不良组(n=54),选取同期本院的120例健康体检者设为对照组。对比不同组别CGRP、EGF、TGF-β1水平及应激指标水平,分析CGRP、EGF、TGF-β1与应激指标、LaneSandhuX线评分的相关性。结果观察组CGRP、EGF、TGF-β1、MDA水平明显高于对照组,SOD水平明显低于对照组,差异均有统计学意义(P<0.05)。愈合良好组CGRP、EGF、TGF-β1、MDA水平明显低于愈合不良组,SOD水平明显高于愈合不良组,差异均有统计学意义(P<0.05)。CGRP、EGF及TGF-β1与SOD水平呈负相关(P<0.05),与MDA水平呈正相关(P<0.05)。CGRP、EGF及TGF-β1水平与Lane-Sandhu X线评分呈负相关(P<0.05)。结论CGRP、EGF、TGF-β1水平可作为观察创伤性骨折患者应激反应、骨折愈合情况的重要指标。

Objective To explore the relationship between the levels of calcitonin⁃generelated pep⁃tide(CGRP),epidermal growth factor(EGF)and transforming growth factor⁃β1(TGF⁃β1)and stress state and fracture healing in patients with traumatic fractures.Methods The 116 patients with traumatic fractures treated in this hospital from May 2017 to May 2019 were selected as the observation group.According to the prognosis,they were divided into a well⁃healed group(n=62)and a poor⁃healed group(n=54).120 subjects with healthy physical examination in this hospital during the same period were selected as the control group.The levels of CGRP,EGF,TGF⁃β1 and stress index levels in different groups were compared,and the corre⁃lation between CGRP,EGF,TGF⁃β1 and stress indexes and LaneSandhu X⁃ray score was analyzed.Results The levels of CGRP,EGF,TGF⁃β1,and MDA in the observation group were significantly higher than those in the control group,and the SOD level was significantly lower than that in the control group,and the differ⁃ences were statistically significant(P<0.05).The levels of CGRP,EGF,TGF⁃β1,and MDA in the well⁃heal⁃ing group were significantly lower than those in the poor⁃healing group,and the SOD levels were significantly higher than those in the poor⁃healing group,and the differences were statistically significant(P<0.05).CGRP,EGF and TGF⁃β1 were negatively correlated with SOD levels(P<0.05),and positively correlated with MDA levels(P<0.05).The levels of CGRP,EGF and TGF⁃β1 were negatively correlated with Lane⁃Sandhu X⁃ray score(P<0.05).Conclusion The levels of CGRP,EGF and TGF⁃β1 can be used as important indicators to observe the stress response and fracture healing in patients with traumatic fractures。