动态监测VEGF、HBP、NGAL在肺癌手术前后水平变化及与预后的关系

Dynamics of serum VEGF,HBP,NGAL levels in lung cancer patients before and after surgery and their relationship with prognosis

目的探讨动态监测VEGF、HBP、NGAL在肺癌手术前后水平变化及与预后的关系。方法选取2017年7月至2020年12月本院80例肺癌患者作为研究对象,根据患者术后复发情况分组,未复发组(n=68)、复发组(n=12)。进行肺癌预后的Cox多因素分析,评价VEGF、HBP、NGAL水平对预后的预测价值,并对比不同水平VEGF、HBP、NGAL患者生存情况。结果两组手术前后VEGF、HBP、NGAL均高于对照组,差异有统计学意义(P<0.05);两组术前VEGF、HBP、NGAL水平相比,差异无统计学意义(P>0.05),术后复发组VEGF、HBP、NGAL水平均高于未复发组,差异有统计学意义(P<0.05);术后VEGF、HBP、NGAL水平均为肺癌患者术后复发影响因素(P<0.05);术后VEGF、HBP、NGAL水平联合对预后的预测AUC最大,具有良好预测效能。结论动态监测VEGF、HBP、NGAL可有效预测肺癌患者术后预后情况,利于评估复发转移风险,开展针对性防治措施。

Objective To investigate the dynamics of VEGF,HBP,NGAL levels before and after lung cancer surgery and their relationship with prognosis.Methods From July 2017 to December 2020,80 patients with lung cancer in our hospital were selected as the research objects,and the patients were grouped according to their recurrence at 1 year after surgery,the non⁃recurring group(n=68)and the recurring group(n=12).The Cox multivariate analysis of the prognosis of lung cancer was performed to evaluate the prognostic value of VEGF,HBP,and NGAL levels,and to compare the survival of patients with different levels of VEGF,HBP,and NGAL.Results The preoperative VEGF,HBP,and NGAL levels were not significantly different between the two groups(P>0.05).The levels of VEGF,HBP,and NGAL in the postoperative recurrence group were higher than those in the non⁃recurrence group,and the postoperative VEGF,HBP,and NGAL levels were all factors affecting postoperative recurrence of lung cancer patients(P<0.05).The combination of VEGF,HBP,and NGAL levels after surgery has the largest prognostic AUC and has good predictive performance.Conclusion Dynamic monitoring of VEGF,HBP,and NGAL can effectively predict the postoperative prognosis of lung cancer patients,which is beneficial to assess the risk of recurrence and metastasis,and carry out targeted prevention and treatment measures.