CD14、HIF-1α、CX3CL1与儿童急性牙髓炎易感性关系及诊断价值

The relationship between CD14,HIF⁃1α,CX3CL1 and susceptibility to acute pulpitis in children and its diagnostic value

目的探讨脂多糖信号受体(CD14)、缺氧诱导因子-1α(HIF-1α)、趋化因子CX3C的配体1(CX3CL1)与儿童急性牙髓炎(AP)易感性的关系。方法选取2018年1月至2020年12月本院收治的82例儿童AP患者(AP组)及40例健康儿童(对照组),比较两组基线资料、CD14、HIF-1α、CX3CL1,并比较不同CD14、HIF-1α、CX3CL1水平患者疼痛视觉模拟评分法(VAS)评分,分析CD14、HIF-1α、CX3CL1与VAS评分关系以及儿童AP易感性的相关影响因素,评价各指标诊断AP的价值。结果 AP组中CD14、HIF-1α、CX3CL1水平高于对照组,差异有统计学意义(P<0.05);CD14、HIF-1α、CX3CL1高水平患者VAS评分高于低水平患者,差异有统计学意义(P<0.05);CD14、HIF-1α、CX3CL1与VAS评分正相关(P<0.05);CD14、HIF-1α、CX3CL1与儿童AP的易感性相关(P<0.05);CD14、HIF-1α、CX3CL1联合诊断AP的曲线下面积(AUC)最大,为0.926。结论血清CD14、HIF-1α、CX3CL1水平升高可能增加儿童AP易感性,并与疼痛程度存在良好线性关系,联合检测上述指标有助于儿童AP诊断。

Objective To investigate the relationship between lipopolysaccharide signal receptor(CD14),hypoxia⁃inducible factor⁃1α(HIF⁃1α),chemokine C⁃X3⁃C motif ligand 1(CX3CL1)and susceptibility to acute pulpitis(AP)in children and evaluate the diagnostic value of the single and combined indicators for children with acute pulpitis.Methods A total of 82 children with AP patients(AP group)and 40 healthy children(control group)treated in our hospital from January 2018 to December 2020 were selected.The baseline data,CD14,HIF⁃1α,and CX3CL1 of the two groups were compared,and the visual analogue scale(VAS)scores of patients with different levels of CD14,HIF⁃1αand CX3CL1 were compared.The relationship between CD14,HIF⁃1α,CX3CL1 and VAS scores,as well as related influencing factors of AP susceptibility in children were analyzed,and the value of each index in the diagnosis of AP was evaluated.Results The levels of CD14,HIF⁃1α,and CX3CL1 in the AP group were higher than those in the control group,and the difference was statistically significant(P<0.05).The VAS scores of patients with high levels of CD14,HIF⁃1α,and CX3CL1 were higher than those with low levels,and the difference was statistically significant(P<0.05).CD14,HIF⁃1α,CX3CL1 were positively correlated with VAS scores(P<0.05).CD14,HIF⁃1α,CX3CL1 were related to the susceptibility of children to AP(P<0.05). The area under the curve(AUC)of CD14, HIF⁃1α,and CX3CL1 in the combined diagnosis of AP was the largest,which was 0.926. Conclusion The elevated levels of serum CD14,HIF⁃1α,and CX3CL1 may increase the susceptibility of children to AP and have a good linear relationship with the degree of pain. The combined detection of the above indicators can help improve the diagnostic value of AP in children.