CRP、LDH、SF预测小儿MPP并发全身炎症反应综合征效能

Efficacy of CRP,LDH and SF in predicting the systemic inflammatory response syndrome in children with MPP

目的探讨C反应蛋白(CRP)、乳酸脱氢酶(LDH)、铁蛋白(SF)预测小儿肺炎支原体肺炎(MPP)并发全身炎症反应综合征(SIRS)的效能。方法选取2017年1月至2020年10月本院MPP患儿102例,根据是否并发SIRS分为SIRS组、无SIRS组,比较两组治疗前、治疗1、2 d后CRP、LDH、SF表达水平,分析并发SIRS影响因素及各指标预测效能。结果两组组间、不同时间点CRP、LDH、SF比较,差异有统计学意义(P<0.05);SIRS组治疗1、2 d后CRP、LDH、SF较治疗前升高,差异有统计学意义(P<0.05),无SIRS组治疗1、2 d后CRP、LDH、SF较治疗前降低,差异有统计学意义(P<0.05);SIRS组治疗1、2 d后CRP、LDH、SF较无SIRS组升高,差异有统计学意义(P<0.05);治疗1 d后、治疗2 d后CRP、LDH、SF升高均是并发SIRS影响因素(P<0.05);治疗1 d后、治疗2 d后CRP、LDH、SF联合预测MPP并发SIRS效能高于单一检测(P<0.05)。结论动态检测MPP患儿CRP、LDH、SF水平能判断病情程度,且能预测SIRS的发生,准确把握MPP发生发展,有助于临床治疗方案的制定与调整。

Objective To investigate the efficacy of C⁃reactive protein(CRP),lactate dehydroge⁃nase(LDH),and serum ferritin(SF)in predicting children with Mycoplasma pneumoniae pneumonia(MPP)complicated by systemic inflammatory response syndrome(SIRS).Methods From January 2017 to October 2020,102 children with MPP in our hospital were selected and divided into the SIRS group and the non⁃SIRS group according to whether they were concurrent with SIRS.The CRP,LDH,and SF were compared between the two groups before treatment and after 1 and 2 days of treatment,and the influencing factors of concurrent SIRS and the predictive efficacy of each indicator were analyzed.Results CRP,LDH and SF were compared between the two groups at different time points,and the difference was statistically significant(P<0.05).The CRP,LDH and SF in the SIRS group increased after 1,2 days of treatment(P<0.05),The CRP,LDH and SF in the non⁃SIRS group decreased after 1,2 days of treatment compared to before treatment(P<0.05).The CRP,LDH,and SF in the SIRS group were higher than those in the non⁃SIRS group after 1 and 2 days of treatment(P<0.05).The increase of CRP,LDH,and SF after 1 and 2 days of treatment are all influencing factors of SIRS(P<0.05).the combination of CRP,LDH,and SF is more effective in predicting MPP complicated by SIRS after 1 and 2 days of treatment than that of single detection(P<0.05).Conclusion Dynamic detection of CRP,LDH and SF levels in children with MPP can judge the severity of the disease,predict the occurrence of SIRS,accurately grasp the oc⁃currence and development of MPP,and help the formulation and adjustment of clinical treatment plans.