中药治疗子宫肌瘤的作用机制研究进展

Research Progress in Mechanism of Chinese Materia Medica in the Treatment of Uterine Leiomyoma

子宫肌瘤是女性生殖系统常见的良性肿瘤之一,其治疗方法包括手术治疗、药物治疗两大类。中医认为子宫肌瘤的核心病机是正虚血瘀,针对该病机运用中药治疗取得了显著效果。本文总结近10年治疗子宫肌瘤的单味中药、药对及成方的作用机制,包括抑制肿瘤细胞增殖、促进肿瘤细胞凋亡、改善血液微循环和血黏稠度、降低激素水平等,为临床治疗子宫肌瘤提供参考依据。

Uterine leiomyoma is a benign tumor which often occurs in female’s genitalia.Its treatment includes surgical treatment and drug treatment.TCM believes that the core pathogenesis of uterine leiomyoma is deficiency of the vital essestial and blood stasis,and the use of Chinese materia medica to treat the pathogenesis has achieved remarkable results.This article summarized the single Chinese materia medica,medicinal pairs and Chinese patent medicines used in the treatment of uterine leiomyoma in the past 10 years,and concluded their mechanism,including inhibiting tumor cell proliferation,promoting tumor cell apoptosis,improving blood microcirculation and blood viscosity,reducing hormone level,in order to provide reference for clinical treatment of uterine leiomyoma.