能量合成障碍在阿尔茨海默病发病中的作用

Role of energy synthesis disorders in pathogenesis of Alzheimer’s disease

阿尔茨海默病(Alzheimer’s disease,AD)是一种多病因导致的疾病,因无有效根治的药物,其早期的病理变化备受关注。大脑作为高能量需求器官,对燃料供应和能量变化非常敏感,葡萄糖代谢紊乱和线粒体功能缺陷是大脑老化的重要标志,也是能量合成障碍的重要环节,早于AD的认知障碍和病理特征,被认为是AD发病的关键环节。该文从脑血流量和脑内葡萄糖摄取、利用以及代谢调控等方面,综述了能量合成障碍在AD发病中的研究进展。

Alzheimer s disease is a neurodegenerative disease with multiple causes.Due to no effective drugs to reverse the progress of AD,many researchers in the world focus on the early pathological changes of AD in order to find the effective intervention for delaying the progress of AD.As an organ with high energy demand,brain is very sensitive to changes in fuel supply and energy alteration.Abnormal glucose metabolism and mitochondrial dysfunction are the important signs of brain aging and the main causes of bioenergetic deficits,which appear earlier than the characteristic pathological injuries of AD.So the disturbance of energy synthesis has been considered an early contributory event to AD progression.In this article we review the study progress of energy synthesis disorder involved in the pathogenesis of AD base on cerebral blood flow,glucose uptake,utilization and the relative metabolic regulation in the brain.