血小板参数与脑梗死CISS分型的相关性研究

Correlation of platelet parameters with CISS staging of cerebral infarction

目的探讨血小板参数与脑梗死、脑梗死CISS分型的相关性。方法选择天津市北辰医院神经内科2018年1月至2019年6月住院治疗的脑梗死住院患者200例作为脑梗死组,选择同期在医院进行体格检查的健康者200例作为对照组,测量血小板参数,将脑梗死患者进行CISS分型,并进行血小板参数与脑梗死、脑梗死CISS分型的相关性分析。结果与对照组相比,脑梗死组血小板计数(PLT)、血小板体积分布宽度(PDW)、血小板压积(PCT)数值较高,但差异无统计学意义。脑梗死患者大型血小板比例(P-LCR)、大血小板数目(P-LCC)数值较高于对照组,差异具有统计学意义(P<0.05);平均血小板体积(MPV)高于对照组,但差异无统计学意义。病例中大动脉粥样硬化(LAA)116例、心源性卒中(CS)28例、穿支动脉疾病(PAD)56例。PLT、PDW、MPV与CISS分型呈正相关,并且PDW、MPV的相关性显著。PCT、P-LCR、P-LCC与CISS分型呈负相关,相关性不显著。P-LCR、P-LCC需要综合更多的临床和患者因素来考虑。结论血小板参数作为一种简单的、临床易获得的血栓形成的血液标记物,具有广泛的应用前景,可初步作为脑梗死病情预估和预后判断的重要指标。

Objective To investigate the correlation between platelet parameters and CISS classification of ischemic stroke and ischemic stroke.Methods A total of 200 inpatients with ischemic stroke and 200 healthy volunteers(as control)in Department of Neurology,Tianjin Beichen Hospital from January 2018 to June 2019 were selected.Platelet parameters were measured,patients with cerebral infarction were classified into CISS classification,and the correlation between platelet parameters and cerebral infarction and CISS classification of cerebral infarction were analyzed.Results Compared with the control group,the platelet count(PLT),platelet volume distribution width(PDW),and platelet packed volume(PCT)in the cerebral infarction group were higher,but the difference was not statistically significant.The proportion of large platelets(P-LCR)and the number of large platelets(P-LCC)in patients with cerebral infarction were higher than those in the control group,and the difference was statistically significant(P<0.05).MPV was higher than the control group,but the difference was not statistically significant.Among the patients,116 cases were large atherosclerosis(LAA),28 cases were cardiac stroke(CS),and 56 cases were perforator artery disease(PAD).PLT,PDW,and MPV were positively correlated with CISS classification,and the correlation between PDW and MPV was significant.PCT,P-LCR,P-LCC,and CISS classification were negatively correlated,and the correlation was not significant.P-LCR and P-LCC needed to consider more clinical use and patient.Conclusion As a simple,clinically accessible blood marker for thrombosis,platelet parameters have broad application prospects,and can be used as an important indicator for the estimation of cerebral infarction and the prognosis.