不可逆电穿孔多因素动态电导率模型的研究与分析

Establishment and Analysis of Multi-Factor Dynamic Conductivity Model for Irreversible Electroporation

不可逆电穿孔肿瘤治疗技术以其独特的非热、可控及微创等特点引起学者的广泛关注。运用准确的术前仿真模型预估消融疗效是实现精准治疗的重要手段,其中组织电导率动态变化的数值表达是准确描述组织内部电场分布的关键。该文在传统电导率模型仅考虑脉冲电场强度及温度影响的基础上,以马铃薯组织为研究对象,运用平行板电极对该组织的电导率进行测量,表征不可逆电穿孔多脉冲累积作用下组织电导率的动态发展规律,并建立随脉冲电场强度、脉冲数目及温度变化的多因素电导率模型。基于建立的数值模型,在针电极施加500V、700V及1000V电压下,流经组织的电流模拟值与实验实测值相对误差平均值低于4%,远小于传统电导率模型与实验电流的误差,验证了模型的准确性。因此,该文提出的电导率多因素模型能够更加准确地描述多脉冲作用下的组织状态变化,为不可逆电穿孔肿瘤术前精准治疗计划的制定奠定理论基础。

Irreversible electroporation tumor treatment technology has attracted widespread attention due to its unique non-thermal,controllable,and minimally invasive.Using an accurate preoperative simulation model to predict the curative effect of ablation is a crucial method to achieve accurate treatment.Among them,the numerical expression of the dynamic conductivity in tissue is the key to describe the electrical field distribution in the tissue accurately.Based on the traditional conductivity model considering only the influence of pulsed electric field strength and temperature,this paper takes potato tissue as the research object,and uses parallel plate electrodes to measure tissue conductivity.The dynamic development law of tissue conductivity under the multi-pulse accumulation of irreversible electroporation is characterized,and a multi-factor conductivity model that varies with pulsed-field strength,pulse number and temperature is established.Then,under 500,700,and 1000V voltage applied to the needle electrode,the error between the simulated current value and the experimental value of the warped tissue is less than 4%,which is much smaller than the error between the traditional conductivity model and the experimental current.Therefore,the multi-factor con-ductivity model proposed in this paper can more accurately describe the change of tissue state under the action of multiple pulses and lay a theoretical foundation for the establishment of precise treatment plans for irreversible electroporation tumors before surgery.