颈动脉超声联合血清微小RNA检测对短期继发脑梗死的诊断价值

Diagnostic value of carotid ultrasound combined with serum micro RNA detection for short-term secondary cerebral infarction

目的研究颈动脉超声联合血清微小RNA检测对短期继发脑梗死的诊断价值。方法选取2019年6月至2020年6月在该院治疗的58例短期继发脑梗死患者纳入短期继发脑梗死组。选取同期在该院体检的58例健康体检者纳入对照组。对患者进行磁共振(MRI)扫描和颈动脉超声检查。检测两组研究对象miR-124、miR-155、miR-23水平。结果短期继发脑梗死组miR-124、miR-155、miR-23水平高于对照组,差异有统计学意义(P<0.05)。颈动脉超声检查对患者颈动脉狭窄程度的检出率,硬膜下出血、脑实质出血、脑室出血、血肿的检出率高于MRI,差异有统计学意义(P<0.05)。颈动脉超声联合miR-124、miR-155、miR-23检测短期继发脑梗死的灵敏度、特异度、准确度较高,差异有统计学意义(P<0.05)。结论颈动脉超声联合miR-124、miR-155、miR-23检测对颈动脉狭窄的诊断价值较高,且可用于预测患者短期继发脑梗死的风险。

Objective To study the diagnostic value of carotid ultrasound combined with serum microRNA for short-term secondary cerebral infarction(CI).Methods Fifty-eight patients with short-term secondary CI treated in this hospital from June 2019 to June 2020 were selected and included into the short-term secondary CI group.Contemporaneous 58 subjects undergoing healthy physical examination in this hospital were selected as the control group.The patients conducted MRI scanning and carotid ultrasound examination.The miR-124,miR-155 and miR-23 levels in all subjects of the two groups were detected.Results The levels of miR-124,miR-155 and miR-23 in the short-term secondary CI were higher than those in the control group,and the difference was statistically significant(P<0.05).The detection rates of carotid ultrasound examination for the carotid arterial stenosis degree,subdural hemorrhage,cerebral parenchyma hemorrhage,ventricular hemorrhage and hematoma was higher than those of the MRI(P<0.05).The sensitivity,specificity and accuracy of carotid ultrasound combined with miR-124,miR-155 and miR-23 detection for diagnosing the short-term secondary CI were high,the difference was statistically significant(P<0.05).Conclusion The carotid ultrasound examination combined with miR-124,miR-155 and miR-23 detection have high diagnostic value for carotid stenosis,moreover can be used to predict the risk of short-term secondary cerebral infarction.