卡介菌多糖核酸联合吸入用布地奈德混悬液治疗支气管哮喘患儿的效果

The Effect of BCG Polysaccharide Nucleic Acid Combined with Budesonide Suspensionfor Inhalation in the Treatment of Children with Bronchial Asthma

目的探讨卡介菌多糖核酸(BCG-PSN)联合吸入用布地奈德混悬液治疗支气管哮喘(BA)患儿的效果。方法选取2019年6月至2020年5月尉氏县人民医院接收的100例BA患儿作为研究对象,采用掷硬币法将其分为两组,各50例。对照组接受吸入用布地奈德混悬液治疗,观察组在对照组基础上接受BCG-PSN治疗,均治疗3个月。对比两组治疗前、治疗3个月时炎症指标[嗜酸性粒细胞阳离子蛋白(ECP)、白细胞介素-8(IL-8)、白细胞介素-13(IL-13)]、血清免疫球蛋白E(IgE)水平及肺功能指标[第一秒用力呼气容积(FEV_1)、用力肺活量(FVC)、最大呼气流量(PEF)],采用儿童哮喘控制测试问卷(C-ACT)评估患儿哮喘控制情况,采用儿科哮喘生命质量调查问卷(PAQLQ)评估患儿生活质量。结果治疗3个月,两组血清ECP、IL-8及IL-13水平均较治疗前低,且观察组更低(P<0.05);治疗3个月,两组血清IgE水平均较治疗前低,且观察组更低(P<0.05);治疗3个月,两组FEV_1、FVC及PEF水平均较治疗前高,且观察组更高(P<0.05);治疗3个月,两组C-ACT评分、PAQLQ各维度评分及总分均较治疗前高,且观察组更高(P<0.05)。结论 BCG-PSN联合吸入用布地奈德混悬液治疗BA患儿可降低其机体炎症反应及变态反应,提高机体免疫力,改善肺功能,控制哮喘症状,提高患儿生活质量。

Objective To investigate the effect of BCG polysaccharide nucleic acid(BCG-PSN)combined with budesonide suspension for inhalation in the treatment of children with bronchial asthma(BA).Methods One hundred children with BA received by Weishi County People’s Hospital from June 2019 to May 2020 were selected as the research subjects.A coin tossing method was used to divide them into two groups,with 50 cases in each group.The control group was treated with budesonide suspension for inhalation,and the observation group was treated with BCG-PSN on the basis of the control group.Both groups were treated for 3 months.Inflammatory indexes[eosinophil cationic protein(ECP),interleukin-8(IL-8),interleukin-13(IL-13)],serum immunoglobulin E(IgE)levels and lung function indexes[forced expiratory volume in the first second(FEV 1),forced vital capacity(FVC),maximum expiratory flow(PEF)]were compared between the two groups before and 3 months after treatment.Asthma control in children was assessed using childhood asthma control test questionnaire(C-ACT),and the quality of life of children was assessed using pediatric asthma quality of life questionnaire(PAQLQ).Results After 3 months of treatment,the serum ECP,IL-8 and IL-13 levels of both groups were lower than before treatment,and the observation group was lower(P<0.05).After 3 months of treatment,the serum IgE levels of both groups were lower than those before treatment,and the observation group was lower(P<0.05).After 3 months of treatment,FEV 1,FVC and PEF levels of both groups were higher than those before treatment,and the observation group was lower(P<0.05).After 3 months of treatment,the each dimension score and total score of C-ACT,PAQLQ of both groups were higher than before treatment,and the observation group was higher(P<0.05).Conclusion BCG-PSN combined with budesonide suspension for inhalation in the treatment of BA children can reduce the body inflammation and allergy reactions,improve the body immunity,improve the lung function,control asthma symptoms and improve the quality of life of children.