维生素K_(2)的生物学效应及临床意义的研究进展

Research progress on the biological effects and clinical significance of vitamin K_(2)

维生素K_(2)是一种强抗氧化生物活性的甲萘醌系列衍生物,能激活人体中的多种关键蛋白,包括凝血因子、骨钙素和基质Gla蛋白等,进而发挥促进凝血功能、促进骨代谢、减少癌变、调节血糖、保护神经以及防止血管硬化等生物学效应,具有重要的临床意义。目前维生素K_(2)已经受到全世界的广泛关注并成为研究热点。本文主要对维生素K_(2)的生物学意义和临床意义进行综述,并展望其研究前景。

Vitamin K_(2)is a series of menadione derivatives with strong antioxidant biological activity,which can activate a variety of key proteins in the human body,including coagulation factors,osteocalcin and matrix Gla protein,etc.Vitamin K_(2)can play the biological effects of promoting blood coagulation,promoting bone metabolism,reducing cancer,regulating blood sugar,protecting nerves and preventing vascular sclerosis,and has important clinical significance.At present,vitamin K_(2)is received widespread attention all over the world and become a research hotspot.This article mainly review the biological and clinical significance of vitamin K 2,and looked forward to its research prospects.