阿卡波糖联合格列吡嗪在首诊2型糖尿病患者中的疗效及对促炎因子的影响

The efficacy of acarbose tablet combined with glipizide in treating patients with first diagnosis of type 2 diabetes mellitus and its influence on proinflammatory factors

目的探讨阿卡波糖片联合格列吡嗪在首诊2型糖尿病(T2DM)患者中的应用效果。方法选择2019年1月—2020年4月本院收治的95例首诊T2DM患者作为研究对象,随机数表法分为联合组(48例)和对照组(47例)两组。两组在接受基础干预的基础上,对照组接受格列吡嗪治疗,联合组予以阿卡波糖片联合格列吡嗪治疗,比较两组治疗前后血糖控制[餐后2 h血糖(2 h PG)、糖化血红蛋白(HbA1c)与空腹血糖(FPG)]水平、胰岛功能[胰岛素抵抗指数(HOMA-IR)、胰岛β细胞功能指数(HOMA-β)]、脂代谢[血清低密度脂蛋白胆固醇(LDL-C)、总胆固醇(TC)]水平、促炎因子[血清趋化素(Chemerin)及内脂素(visfatin)]。结果治疗后联合组2 h PG、FPG与HbA1c水平均较对照组降低(P<0.05);治疗后联合组HOMA-IR水平低于对照组,HOMA-β水平高于对照组(P<0.05);治疗后联合组血清LDL-C、TC水平较对照组降低(P<0.05);治疗后联合组血清Chemerin、visfatin水平低于对照组(P<0.05)。结论阿卡波糖片联合格列吡嗪治疗首诊T2DM患者,可有效控制患者血糖与脂代谢水平,改善胰岛功能,降低促炎因子表达。

Objective To investigate the effect of acarbose tablet combined with glipizide in treating patients with first diagnosis of type 2 diabetes mellitus(T2 DM).Methods A total of 95 patients with T2 DM who were first diagnosed in our hospital from January 2019 to April 2020 were enrolled as study subjects and they were randomly divided into combination group(n=48)and control group(n=47)according to random number table method.Based on the basic intervention,the patients in the control groupreceived glipizide treatment,and patients in the combination group(48 cases)received acarbose tablet combined with glipizide for treatment.The levels of blood glucose control[glucose at 2 h postprandial(2 hPG),glycosylated hemoglobin(HbA1 c),fasting blood-glucose(FBG)],islet function[homeostasis model assessment of insulin resistance(HOMA-IR),homeostasis model assessment of pancreaticβcell(HOMA-β)],lipid metabolism[low density lipoprotein cholesterol(LDL-C),total cholestasis(TC)],pro-inflammatory factors[Chemerin and visfatin]were compared between the two groups before and after treatment.Results After treatment,the levels of 2 hPG,FPG and HbA1 c in combination group were lower than those in control group(P<0.05).After treatment,the level of HOMA-IR in combination group was lower than that in control group,and the level of HOMA-βwas higher than that in control group(P<0.05).After treatment,serum LDL-C and TC levels in combination group were lower than those in control group(P<0.05).After treatment,the serum levels of Chemerin and visfatin in combination group were lower than those in control group(P<0.05).Conclusions Acarbose tablet combined with glipizide could effectively control blood glucose and lipid metabolism,improve islet function,and reduce the expression of pro-inflammatory factors in patients with first-diagnosed T2 DM.