集束化营养干预对非霍奇金淋巴瘤患者营养状况和生存质量的影响

Effect of bundle nutrition intervention on nutritional status and quality of life in patients with non-Hodgkin lymphoma

目的探讨集束化营养干预措施对非霍奇金淋巴瘤(NHL)患者营养状况和生存质量的影响。方法84例NHL化疗患者,应用随机数字表法分为研究组和对照组,每组42例。两组化疗方案一致,对照组给予常规饮食指导,研究组在对照组基础上实施集束化营养干预措施。比较两组入院时和化疗后的营养状况及生存质量。结果化疗后,两组有营养风险占比比较,差异无统计学意义(P>0.05),研究组患者血清白蛋白(ALB)(31.6±3.7)g/L、前白蛋白(PA)(0.30±0.06)g/L、血红蛋白(Hb)(11.4±2.2)g/dl、总淋巴细胞计数(TLC)(1.56±0.44)×109/L均高于对照组的(28.4±4.5)g/L、(0.23±0.04)g/L、(9.6±2.6)g/dl、(1.35±0.42)×109/L,差异均具有统计学意义(P<0.05)。化疗后,研究组患者生理领域评分(60.2±5.0)分、心理领域评分(61.2±5.2)分、社会关系领域评分(58.6±5.2)分、环境领域评分(59.6±4.2)分、总评分(59.8±5.3)分均高于对照组的(55.4±4.6)、(57.3±4.8)、(54.4±5.1)、(55.4±4.8)、(56.2±4.5)分,差异均具有统计学意义(P<0.05)。结论集束化营养干预能改善非霍奇金淋巴瘤患者营养状况和生存质量。

Objective To discuss the effect of bundle nutrition intervention on nutritional status and quality of life in patients with non-Hodgkin lymphoma(NHL).Methods A total of 84 patients with NHL were divided into study group and control group according to random numerical table,with 42 cases in each group.The chemotherapy regimens in the two groups were the same.The control group received routine diet guidance,and the research group received bundle nutrition intervention based on the control group.The nutritional status and quality of life of the two groups at admission and after chemotherapy were compared.Results After chemotherapy,there was no statistically significant difference in the proportion of nutritional risks between the two groups(P>0.05).The serum albumin(ALB)(31.6±3.7)g/L,prealbumin(PA)(0.30±0.06)g/L,hemoglobin(Hb)(11.4±2.2)g/dl,total lymphocyte count(TLC)(1.56±0.44)×109/L of the research group were higher than(28.4±4.5)g/L,(0.23±0.04)g/L,(9.6±2.6)g/dl,(1.35±0.42)×109/L of the control group,and the difference was statistically significant(P<0.05).After chemotherapy,the physiological field score(60.2±5.0)points,psychological field score(61.2±5.2)points,social relationship field score(58.6±5.2)points,environmental field score(59.6±4.2)points and total score(59.8±5.3)points of the research group were higher than(55.4±4.6),(57.3±4.8),(54.4±5.1),(55.4±4.8),(56.2±4.5)points of the control group,and the differences were statistically significant(P<0.05).Conclusion Bundle nutrition intervention can significantly improve the nutritional status and quality of life of patients with non-Hodgkin lymphoma.