冠脉介入治疗冠心病急性心肌梗死的效果及对患者心室功能的影响

The effect of coronary intervention on acute myocardial infarction of coronary heart disease and its influence on the ventricular function of patients

目的探讨冠脉介入治疗冠心病急性心肌梗死的效果及对患者心室功能的影响。方法98例冠心病急性心肌梗死患者,按照计算机编号的单双数分为观察组(双数)与对照组(单数),各49例。对照组采用静脉溶栓治疗,观察组采用冠脉介入治疗。比较两组治疗前后的B型利钠肽(BNP)水平、心室功能、心肌酶指标。结果治疗后第7、14天,观察组BNP水平分别为(501.24±108.69)、(314.65±67.92)ng/L,均低于对照组的(813.45±112.38)、(804.61±66.45)ng/L,差异有统计学意义(P<0.05)。治疗后,观察组左心室舒张末期容积(LVEDV)、左心室收缩末期容积(LVESV)低于对照组,左心室射血分数(LVEF)高于对照组,差异有统计学意义(P<0.05)。两组肌酸激酶(CK)峰值、肌酸激酶同工酶(CKMB)峰值比较,差异无统计学意义(P>0.05);观察组CK峰值出现时间、CK-MB峰值出现时间均短于对照组,差异有统计学意义(P<0.05)。结论采用冠脉介入治疗冠心病急性心肌梗死,可明显改善心功能指标,修复受损神经功能。

Objective To discuss the effect of coronary intervention on acute myocardial infarction of coronary heart disease and its influence on the ventricular function of patients.Methods A total of 98 patients with acute myocardial infarction of coronary heart disease were divided into observation group(even number)and control group(odd number)according to computer serial number,with 49 cases in each group.The control group was treated with intravenous thrombolysis,and the observation group was treated with coronary intervention.The B-type natriuretic peptide(BNP),ventricular function,myocardial enzyme index before and after treatment were compared between the two groups.Results 7 and 14 days after treatment,the BNP of the observation group were(501.24±108.69)and(314.65±67.92)ng/L,which were lower than(813.45±112.38)and(804.61±66.45)ng/L of the control group,and the difference was statistically significant(P<0.05).After treatment,the left ventricular end-diastolic volume(LVEDV),left ventricular end-systolic volume(LVESV)of the observation group were lower than those of the control group,and the left ventricular ejection fraction(LVEF)was higher than that of the control group.All the difference was statistically significant(P<0.05).There was no statistically significant difference in peak creatine kinase(CK)and peak creatine kinase isoenzyme(CK-MB)between the two groups(P>0.05).The peak time of CK and CK-MB in the observation group was significantly shorter than that in the control group,and the difference was statistically significant(P<0.05).Conclusion Coronary intervention in the treatment of acute myocardial infarction in coronary heart disease can significantly improve the cardiac function indicators and repair the damaged nerve function.