丙戊酸镁缓释片在躁狂发作患者中的应用效果及对认知功能的影响研究

Practical effect of magnesium valproate sustained release tablets in manic episode patients and its influence on cognitive function

目的探讨丙戊酸镁缓释片在躁狂发作患者中的应用效果及对认知功能的影响。方法90例躁狂发作患者,随机分为对照组和观察组,每组45例。对照组采用碳酸锂缓释片治疗,观察组采用丙戊酸镁缓释片治疗。比较两组症状改善情况、认知功能、记忆力、持续注意力及不良反应评分。结果治疗6周后,观察组动作、语言、工作、吵闹、敌意、情绪、睡眠、接触、意念飘忽及自我评价评分均优于对照组,差异有统计学意义(P<0.05);两组性欲评分比较,差异无统计学意义(P>0.05)。治疗后,观察组持续错误数、错误应答数、持续应答数、完成分类数、连线测验(TMT)A用时、TMTB用时均优于对照组,差异有统计学意义(P<0.05)。治疗后,观察组言语记忆力测验(HVLT-R)评分(27.65±5.37)分、持续性操作测验(CPT)评分(3.14±1.34)分高于对照组的(24.85±5.16)、(2.59±1.06)分,副反应量表(TESS)评分(3.98±2.36)分低于对照组的(5.61±2.84)分,差异有统计学意义(P<0.05)。结论丙戊酸镁缓释片在躁狂发作患者中的应用效果良好,可明显改善患者的认知功能,提升患者的生活质量,不良反应较少,值得推广应用。

Objective To discuss the practical effect of magnesium valproate sustained release tablets in manic episode patients and its influence on cognitive function.Methods A total of patients with manic episode were randomly divided into control group and observation group,with 45 cases in each group.The control group was treated with lithium carbonate sustained-release tablets,and the observation group was treated with magnesium valproate sustained release tablets.The improvement of symptoms,cognitive function,memory,sustained attention,and adverse reactions score were compared between the two groups.Results After 6 months of treatment,the action,language,work,noise,hostility,emotion,sleep,contact,wandering and self-evaluation score of the observation group were better than those of the control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in sexual desire score between the two groups(P>0.05).After treatment,the number of continuous errors,wrong answers,continuous answers,completed categories,trail-making test(TMT)time and TMTB time of the observation group were better than those of the control group,and the difference was statistically significant(P<0.05).After treatment,the hopkins verbal learning test-revised(HVLT-R)score(27.65±5.37)points and continue performance test(CPT)score(3.14±1.34)points of the observation group were higher than(24.85±5.16)and(2.59±1.06)points of the control group,and the treatment emergent symptom scale(TESS)score(3.98±2.36)points was lower than(5.61±2.84)points of the control group.All the difference was statistically significant(P<0.05).Conclusion Magnesium valproate sustained release tablets has good practical effect on patients with manic episode,and it can obviously improve the cognitive function and quality of life of patients with less adverse reactions,which is worthy of promotion and application.