阿司匹林联合氯吡格雷对脑梗死的治疗效果

Therapeutic effect of aspirin combined with clopidogrel on cerebral infarction

目的探讨阿司匹林联合氯吡格雷治疗脑梗死(CI)的临床价值。方法80例CI患者,根据随机数字表法分成对照组与观察组,各40例。对照组单纯采用阿司匹林治疗,观察组在对照组基础上联合氯吡格雷治疗。比较两组临床疗效、美国国立卫生研究院卒中量表(NIHSS)评分、Barthel指数及不良反应发生情况。结果观察组治疗总有效率为95.0%(38/40),高于对照组的77.5%(31/40),差异具有统计学意义(P<0.05)。治疗后,观察组NIHSS评分(10.21±2.16)分低于治疗前的(23.42±3.51)分,Barthel指数(85.57±10.22)分均高于治疗前的(60.52±8.53)分;对照组NIHSS评分(17.52±3.21)分低于治疗前的(22.81±4.15)分,Barthel指数(74.63±9.82)分均高于治疗前的(60.83±8.82)分;且观察组NIHSS评分低于对照组,Barthel指数高于对照组,差异具有统计学意义(P<0.05)。观察组不良反应发生率为5.0%(2/40),低于对照组的22.5%(9/40),差异具有统计学意义(P<0.05)。结论阿司匹林联合氯吡格雷治疗CI患者的疗效确切,治疗后患者神经功能缺损情况明显改善,建议推广应用。

Objective To discuss the clinical value of aspirin combined with clopidogrel on cerebral infarction(CI).Methods A total of 80 CI patients were divided into control group and observation group according to random numerical table,with 40 cases in each group.The control group was treated with aspirin,and the observation group was treated with clopidogrel based on the control group.The clinical efficacy,National Institutes of Health stroke scale(NIHSS)score,Barthel index and occurrence of adverse reactions were compared between the two groups.Results The total effective rate of the observation group was 95.0%(38/40),which was higher than 77.5%(31/40)of the control group,and the difference was statistically significant(P<0.05).In the observation group,the NIHSS score(10.21±2.16)points after treatment was lower than(23.42±3.51)points before treatment,and Barthel index(85.57±10.22)points was higher than(60.52±8.53)points before treatment.In the control group,the NIHSS score(17.52±3.21)points after treatment was lower than(22.81±4.15)points before treatment,and the Barthel index(74.63±9.82)points was higher than(60.83±8.82)points before treatment.After treatment,the NIHSS score of the observation group was lower than that of the control group,and the difference was statistically significant(P<0.05).The incidence of adverse reactions of the observation group was 5.0%(2/40),which was lower than 22.5%(9/40)of the control group,and the difference was statistically significant(P<0.05).Conclusion Combination of aspirin and clopidogrel has affirmative efficacy on CI patients,and it can obviously improve the neurological deficit,which is worthy of promotion and application.